CLK1/4-IN-1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CLK1/4-IN-1 

CLK1/4-IN-1 (compound 31) 是一种有效且具有选择性的 Clk1 和 Clk4 抑制剂，IC50 分别为 9.7 nM 和 6.6 nM。CLK1/4-IN-1 对 T24 癌细胞的生长具有抑制活性，GI50 为 1.1 μM。CLK1/4-IN-1 可用于抗癌研究。

CLK1/4-IN-1

CLK1/4-IN-1 Chemical Structure

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生物活性

CLK1/4-IN-1 (compound 31) is a potent and selective Clk1 and Clk4 inhibitor with an IC50 value of 9.7 nM and 6.6 nM, respectively. CLK1/4-IN-1 has growth inhibitory activities against T24 cancer cells with GI50 of 1.1 μM. CLK1/4-IN-1 can be used for researching anticancer[1].

IC50 & Target[1]

CLK1

9.7 nM (IC50)

CLK4

6.6 nM (IC50)

分子量

375.83

Formula

C18H14ClNO4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. El-Gamil DS, et al. Development of novel conformationally restricted selective Clk1/4 inhibitors through creating an intramolecular hydrogen bond involving an imide linker [published online ahead of print, 2022 Apr 26]. Eur J Med Chem. 2022;238:114411.

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