Antiproliferative against-6

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Antiproliferative against-6 

Antiproliferative against-6 (compound 4o) 对胃癌细胞增殖有明显的不可逆抑制作用。Antiproliferative against-6 可引起细胞在 G2/M 期阻滞，诱导 ROS 积累，激活细胞自噬 (autophagy)。Antiproliferative against-6 可用于抗癌研究。

Antiproliferative against-6

Antiproliferative against-6 Chemical Structure

CAS No. : 2459892-41-0

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生物活性

Antiproliferative against-6 (compound 4o) can significantly and irreversibly inhibit proliferation of gastric cancer cells. Antiproliferative against-6 causes the G2/M phase arrest, and induces ROS accumulation and activation of autophagy. Antiproliferative against-6 can be used for researching anticancer[1].

IC50 & Target

ROS, Autophagy[1]
分子量

597.49

Formula

C28H21BrN8OS
CAS 号

2459892-41-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wang S, et al. Discovery of new [1,2,4] Triazolo[1,5-a]Pyrimidine derivatives that Kill gastric cancer cells via the mitochondria pathway. Eur J Med Chem. 2020;203:112630.

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