ZLHQ-5f

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ZLHQ-5f 

ZLHQ-5f 是一种 CDK2 和 Topo I 双重抑制剂，对 CDK2/CycA2 的 IC50 值为 0.145 μM。ZLHQ-5f 在 S 期阻滞细胞周期，诱导 HCT116 细胞凋亡 (apoptosis)，具有良好安全性。

ZLHQ-5f

ZLHQ-5f Chemical Structure

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生物活性

ZLHQ-5f is a dual CDK2 and Topo I inhibitor with an IC50 of 0.145 μM against CDK2/CycA2. ZLHQ-5f arrests the cell cycle in S-phase, triggers apoptosis in HCT116 cells, and has a good safety profile[1].

IC50 & Target

CDK2/CycA2

0.145 μM (IC50)

Top1

 

体外研究
(In Vitro)

ZLHQ-5f shows antiproliferative activity with GI50 values of 0.949 ± 0.113, 0.821 ± 0.240, 1.124 ± 0.362, 1.945 ± 0.278 and 3.349 ± 0.149 μM against A549, HCT116, MCF-7, HepG2 and LO2 cells, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

463.53

Formula

C28H25N5O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Huang Y, et al. Discovery of novel benzofuro[3,2-b]quinoline derivatives as dual CDK2/Topo I inhibitors. Bioorg Chem. 2022 May 21;126:105870.

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