CB2R probe 1

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CB2R probe 1 

CB2R probe 1 是一种安全绿色的 CB2R (2 型大麻素受体) 荧光探针，Ki 为 130 nM。CB2R probe 1 在癌细胞中显示出低细胞毒性。

CB2R probe 1

CB2R probe 1 Chemical Structure

CAS No. : 2634714-79-5

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生物活性

CB2R probe 1 is a safe and green CB2R (cannabinoid 2 receptor) fluorescent probe with an Ki of 130 nM. CB2R probe 1 shows low cytotoxicity in cancer cells[1].

IC50 & Target[1]

cannabinoid type-2 receptors

130 nM (Ki)

体外研究
(In Vitro)

CB2R probe 1 (compound 28) (100 nM; 24 h) shows low cytotoxicity with IC50s of 1.6, 1.4, 1.4, 1.1, 2.6, 0.55, 2.0, 2.4, 2.8 nM for PANC1, U2OS, HT29, HT29-DX, U87AD, PC3, CB2R-HEK293, MCF7, MCFT-DX cells, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

594.74

Formula

C36H42N4O4
CAS 号

2634714-79-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Spinelli F, et al. Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R). Eur J Med Chem. 2020 Feb 15;188:112037.

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