Tripchlorolide

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Tripchlorolide 

Tripchloride 是一种神经保护剂,存在于 Tripterygium wilfordii 中。Tripchloride 通过诱导细胞凋亡和自噬来防止肿瘤生长。Tripchloride 可改善阿尔茨海默病患者的认知缺陷。

Tripchlorolide Tripchlorolide

Tripchlorolide Chemical Structure

CAS No. : 132368-08-2

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生物活性

Tripchlorolide is a neuroprotective agent that can be found in Tripterygium wilfordii. Tripchlorolide prevents tumor growth by inducing apoptosis and autophagy. Tripchlorolide improves cognitive deficits in Alzheimer’s disease[1][2][3].

分子量

396.86

Formula

C20H25ClO6

CAS 号

132368-08-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Li FQ, et, al. Neurotrophic and neuroprotective effects of tripchlorolide, an extract of Chinese herb Tripterygium wilfordii Hook F, on dopaminergic neurons. Exp Neurol. 2003 Jan;179(1):28-37.

    [2]. Chen L, et, al. Tripchlorolide induces cell death in lung cancer cells by autophagy. Int J Oncol. 2012 Apr;40(4):1066-70.

    [3]. Zeng Y, et, al. Tripchlorolide improves cognitive deficits by reducing amyloid β and upregulating synapse-related proteins in a transgenic model of Alzheimer’s Disease. J Neurochem. 2015 Apr;133(1):38-52.

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