Anticancer agent 48

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Anticancer agent 48 

Anticancer agent 48 (compound 48) 是一种广谱抗癌剂。Anticancer agent 48 抑制微管蛋白聚合。Anticancer agent 48 表现出抗增殖活性。Anticancer agent 48 在体内显示抗肿瘤活性。Anticancer agent 48 具有研究实体瘤和血液肿瘤的潜力。

Anticancer agent 48

Anticancer agent 48 Chemical Structure

CAS No. : 2395009-13-7

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生物活性

Anticancer agent 48 (compound 48) is a broad spectrum anticancer agent. Anticancer agent 48 inhibits tubulin polymerization. Anticancer agent 48 shows antiproliferative activity. Anticancer agent 48 shows antitumor activity in vivo. Anticancer agent 48 has the potential for the research of solid and hematological tumors[1].

体外研究
(In Vitro)

Anticancer agent 48 (compound 48) inhibits tubulin polymerization and MCF-7 cancer cell growth with IC50s of 0.47 µM and 14 nM, respectively[1].
Anticancer agent 48 shows antiproliferative activity with IC50s of 8, 10, 12, 14, 16 nM for KU812, LAMA84-S, LAMA84-R, KBM5-WT, KBM5-T315I cells, respectively[1].
Anticancer agent 48 shows growth inhibition with IC50s of 12, 31, 37, 221, 56, 27, 51, 48, 28, 12 nM for U343G, U87MG, T98G, SK-N-BE, SK-N-BE(2)-C, HT29, HCT116, SW480, SW620, T24 cell, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Anticancer agent 48 (20 mg/kg; i.p.; every 2 days for 40 days) shows antitumor effects[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8 week-old female BALB/Cnu/nu mice (EZ-2 or T24 cells)[1]
Dosage: 20 mg/kg
Administration: I.p.; every 2 days for 40 days
Result: Significantly inhibited cancer cell proliferation, in vivo tumorigenesis, and tumor angiogenesis.

分子量

443.49

Formula

C26H25N3O4
CAS 号

2395009-13-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Puxeddu M, et al. Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies. Eur J Med Chem. 2020 Jan 1;185:111828.

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