Bimolane(Synonyms: AT-1727)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Bimolane (Synonyms: AT-1727)

Bimolane (AT-1727) 是一种人类拓扑异构酶 II 抑制剂,可用作抗肿瘤剂和用于银屑病的研究。Bimolane 显示出致白血病活性并在人淋巴细胞中诱导多种类型的染色体畸变。

Bimolane(Synonyms: AT-1727)

Bimolane Chemical Structure

CAS No. : 74550-97-3

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生物活性

Bimolane (AT-1727), a human topoisomerase II inhibitor, can be used as an anti-neoplastic agent and for the research of psoriasis. Bimolane shows leukemogenic activity and induces multiple types of chromosomal aberrations in human lymphocytes[1][2].

IC50 & Target[1]

Topoisomerase II

 

分子量

452.50

Formula

C20H32N6O6

CAS 号

74550-97-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Frantz CE, et, al. Bimolane: in vitro inhibitor of human topoisomerase II. Cancer Lett. 1997 Dec 9;120(2):135-40.

    [2]. Roy SK, et, al. Bimolane induces multiple types of chromosomal aberrations in human lymphocytes in vitro. Mutat Res. 2011 Dec 24;726(2):181-7.

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