Antitumor agent-63

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Antitumor agent-63 

Antitumor agent-63 (Compound 40),20 (S)-O-linked camptothecin (CPT) 糖复合物,是一种抗肿瘤剂,对正常细胞无毒性。Antitumor agent-63 具有高稳定性和很弱的 topoisomerase I (Topo I) 直接抑制效果。

Antitumor agent-63

Antitumor agent-63 Chemical Structure

CAS No. : 1627600-90-1

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生物活性

Antitumor agent-63 (Compound 40), a 20 (S)-O-linked camptothecin (CPT) glycoconjugate, is an antitumor agent without toxicity towards normal cells. Antitumor agent-63 shows high stability and very weak direct topoisomerase I (Topo I) inhibition[1].

IC50 & Target

Top1

 

体外研究
(In Vitro)

Antitumor agent-63 (Compound 40) shows cytotoxicity activities with IC50 values of 1.2, 0.8, 30.5 and >100 µM against HepG2, HCT-116, SW1990 and HEK-293, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

846.79

Formula

C38H46N4O18

CAS 号

1627600-90-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Li M, et al. Oligosaccharide-camptothecin conjugates as potential antineoplastic drugs: Design, synthesis and biological evaluation. Eur J Med Chem. 2020 Sep 15;202:112509.

Cell Assay

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献
  • [1]. Li M, et al. Oligosaccharide-camptothecin conjugates as potential antineoplastic drugs: Design, synthesis and biological evaluation. Eur J Med Chem. 2020 Sep 15;202:112509.

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