Doxycycline hydrochloride(Synonyms: 盐酸多西环素)

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Doxycycline hydrochloride (Synonyms: 盐酸多西环素)

Doxycycline hydrochloride 是一种具有口服活性的四环素抗生素，是广谱的金属蛋白酶 (MMP) 抑制剂，具有抗菌活性和抗癌细胞增殖活性。

Doxycycline hydrochloride(Synonyms: 盐酸多西环素)

Doxycycline hydrochloride Chemical Structure

CAS No. : 10592-13-9

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Doxycycline hydrochloride 的其他形式现货产品:

Doxycycline Doxycycline (hyclate)

生物活性

Doxycycline hydrochloride, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1]. Doxycycline hydrochloride shows antibacterial activity and anti-cancer cell proliferation activity[1][2][3][4][5].

体外研究
(In Vitro)

Doxycycline hydrochloride (0.01-10 µg/mL, 4 d) affects growth of glioma cells only under high concentrations[2].
Doxycycline hydrochloride (0.01-10 µg/mL, 24 h) decreases MT-CO1 protein content with concentrations of 1 µg/mL and higher in SVG cells[2].
Doxycycline hydrochloride (100 ng/mL, 1 µg/mL; 24 h) reduces proliferation of human cell lines[4].
Doxycycline hydrochloride (0-250 μM, 72 h) inhibits cell viability of breast cancer cells [5].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: LNT-229, G55, and U343 glioma cells
Concentration: 0.01, 0.1, 1 or 10 µg/mL
Incubation Time: 4 days
Result: Affected growth of glioma cells only under high concentrations.

Cell Viability Assay[2]

Cell Line: SVG cells
Concentration: 0.01, 0.1, 1 or 10 µg/mL
Incubation Time: 24 hours
Result: Decreaseed MT-CO1 protein content with concentrations of 1 µg/mL and higher.

Cell Proliferation Assay[4]

Cell Line: MCF 12A, 293T cells
Concentration: 100 ng/mL, 1 µg/mL
Incubation Time: 96 hours
Result: Caused reduced proliferation of MCF 12A and 293T cells at 1 µg/mL.

Cell Viability Assay[5]

Cell Line: MCF-7, MDA-MB-468 cells
Concentration: 0-250 μM
Incubation Time: 72 hours
Result: Inhibited breast cancer cells in a dose-dependent manner with IC50 values for MCF-7 and MDA-MB-468 of 11.39 μM and 7.13 μM respectively.

体内研究
(In Vivo)

Doxycycline hydrochloride (oral gavage; 200 or 800 mg/kg; once daily; 3 months) reduces MMP-9 activity in untreated HT mice in a dose-dependent manner[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-month-old female Heterozygous Col3a1-deficient (HT) mice[3]
Dosage: 200 or 800 mg/kg
Administration: Oral gavage; 200 or 800 mg/kg; once daily; 3 months
Result: Reduced MMP-9 activity in a dose-dependent manner.

Clinical Trial

分子量

480.90

Formula

C22H25ClN2O8
CAS 号

10592-13-9
中文名称

盐酸多西环素；盐酸强力霉素盐；多西环素盐酸盐；去氧土霉素盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Eusebio Manchado, et al. A combinatorial strategy for treating KRAS-mutant lung cancer. Nature. 2016 Jun 30;534(7609):647-51.

    [2]. Anna-Luisa Luger, et al. Doxycycline Impairs Mitochondrial Function and Protects Human Glioma Cells from Hypoxia-Induced Cell Death: Implications of Using Tet-Inducible Systems. Int J Mol Sci. 2018 May 17;19(5):1504.

    [3]. Wilfried Briest, et al. Doxycycline ameliorates the susceptibility to aortic lesions in a mouse model for the vascular type of Ehlers-Danlos syndrome. J Pharmacol Exp Ther. 2011 Jun;337(3):621-7.

    [4]. Ethan Ahler, et al. Doxycycline alters metabolism and proliferation of human cell lines. PLoS One. 2013 May 31;8(5):e64561.

    [5]. Le Zhang, et al. Doxycycline inhibits the cancer stem cell phenotype and epithelial-to-mesenchymal transition in breast cancer. Cell Cycle. 2017 Apr 18;16(8):737-745.

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