Methotrexate monohydrate(Synonyms: Amethopterin monohydrate; CL14377 monohydrate; WR19039 monohydrate)

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Methotrexate monohydrate (Synonyms: Amethopterin monohydrate; CL14377 monohydrate; WR19039 monohydrate)

Methotrexate (Amethopterin) monohydrate 是一种抗代谢 (antimetabolite) 和抗叶酸剂 (antifolate)，可抑制二氢叶酸还原酶，从而防止叶酸转化为四氢叶酸并抑制 DNA 合成。Methotrexate monohydrate 也是一种免疫抑制剂和抗肿瘤剂，用于类风湿关节炎和研究多种癌症 (如急性淋巴细胞白血病)。

Methotrexate monohydrate(Synonyms: Amethopterin monohydrate; CL14377 monohydrate; WR19039 monohydrate)

Methotrexate monohydrate Chemical Structure

CAS No. : 6745-93-3

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Methotrexate monohydrate 的其他形式现货产品:

Methotrexate Methotrexate disodium Methotrexate-d3

生物活性

Methotrexate (Amethopterin) monohydrate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate monohydrate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3].

IC50 & Target

Traditional Cytotoxic Agents

 

体内研究
(In Vivo)

Methotrexate (Amethopterin) monohydrate reduces thymus and spleen indices of mice. Methotrexate monohydrate markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate monohydrate exposure on indices of thymus and spleens in mice[2].
Methotrexate (MTX) monohydrate (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freund’s complete adjuvant-induced arthritis. The combination of Methotrexate monohydrate (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

472.45

Formula

C20H24N8O6
CAS 号

6745-93-3
中文名称

甲氨蝶呤一水合物；氨甲蝶呤一水合物；氨甲叶酸一水合物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tian H, et al. Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis. Bull NYU Hosp Jt Dis. 2007;65(3):168-73.

    [2]. Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92.

    [3]. Ehab Tousson, et al. The Effect of L-carnitine on Amethopterin-induced Toxicity in Rat Large Intestine.

    [4]. Banji D, et al. Evaluation of the concomitant use of methotrexate and curcumin on Freund’s complete adjuvant-induced arthritis and hematological indices in rats. Indian J Pharmacol. 2011;43(5):546-550.

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