生物活性分子抑制剂Sodium oleate(Synonyms: Oleic acid sodium; 9-cis-Octadecenoic acid sodium; 9Z-Octadecenoic acid sodium)

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Sodium oleate (Synonyms: Oleic acid sodium; 9-cis-Octadecenoic acid sodium; 9Z-Octadecenoic acid sodium) 纯度: ≥98.0%

Sodium oleate (Oleic acid sodium) 是人脂肪细胞和其他组织中最常见的单不饱和脂肪酸钠盐。Sodium oleate 是一种 Na+/K+ ATP 酶激活剂。

Sodium oleate(Synonyms: Oleic acid sodium; 9-cis-Octadecenoic acid sodium; 9Z-Octadecenoic acid sodium)

Sodium oleate Chemical Structure

CAS No. : 143-19-1

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10 mM * 1 mL in Water ￥550 In-stock
100 mg ￥500 In-stock
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生物活性

Sodium oleate (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium[1]. Sodium oleate is a Na+/K+ ATPase activator[2].

IC50 & Target

Na+/K+ ATPase[2]
体外研究
(In Vitro)

Oleic acid is the most common monounsaturated fatty acids (FA) in human adipocytes and other tissues. Oleic acid prompts cell proliferation and migration in high metastatic cancer cells via enhancing β-oxidation mediated by AMPK activation. Oleic acid inhibits cancer cell growth and survival in low metastatic carcinoma cells, such as gastric carcinoma SGC7901 and breast carcinoma MCF-7 cell lines[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

304.44

Formula

C18H33NaO2
CAS 号

143-19-1
中文名称

油酸钠
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

H2O : 25 mg/mL (82.12 mM; Need ultrasonic)

DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.2847 mL 16.4236 mL 32.8472 mL
5 mM 0.6569 mL 3.2847 mL 6.5694 mL
10 mM 0.3285 mL 1.6424 mL 3.2847 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Li S, et al. High metastaticgastric and breast cancer cells consume oleic acid in an AMPK dependent manner. PLoS One. 2014 May 13;9(5):e97330.

    [2]. Jack-Hays MG, et al. Activation of Na+/K(+)-ATPase by fatty acids, acylglycerols, and related amphiphiles: structure-activity relationship. Biochim Biophys Acta. 1996 Feb 21;1279(1):43-8.

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