上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Flucytosine (Synonyms: 5-氟胞嘧啶; 5-Fluorocytosine; NSC 103805; Ro 2-9915) 纯度: 99.77%
Flucytosine(5-Fluorocytosine, 5-FC, Ancobon)是抗真菌化合物。
Flucytosine Chemical Structure
CAS No. : 2022-85-7
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥500 | In-stock | |
500 mg | ¥350 | In-stock | |
1 g | ¥450 | In-stock | |
5 g | ¥1030 | In-stock | |
10 g | 询价 | ||
50 g | 询价 |
* Please select Quantity before adding items.
Flucytosine 相关产品
•相关化合物库:
- Drug Repurposing Compound Library Plus
- FDA-Approved Drug Library Plus
- FDA-Approved Drug Library Mini
- Bioactive Compound Library Plus
- Anti-Infection Compound Library
- FDA-Approved Drug Library
- Anti-Cancer Compound Library
- CNS-Penetrant Compound Library
- Drug Repurposing Compound Library
- Nucleotide Compound Library
- Antifungal Compound Library
- Anti-COVID-19 Compound Library
- NMPA-Approved Drug Library
- Orally Active Compound Library
- FDA Approved & Pharmacopeial Drug Library
- Antibiotics Library
- Drug-Induced Liver Injury (DILI) Compound Library
- Rare Diseases Drug Library
- Children’s Drug Library
生物活性 |
Flucytosine (5-Fluorocytosine, 5-FC, Ancobon), a fluorinated pyrimidine analogue, is an antifungal drug. Target: antifungal Flucytosine, or 5-fluorocytosine, a fluorinated pyrimidine analogue, is a synthetic antimycotic drug. It is structurally related to the cytostatic fluorouracil and to floxuridine. It is available in oral and in some countries also in injectable form. A common brand name is Ancobon. Flucytosine was first synthesized in 1957 but its antifungal properties were discovered in 1964. The drug is dispensed in capsules of 250 mg and 500 mg strength. The injectable form is diluted in 250 mL saline solution to contain 2.5 g total (10 mg/mL). The solution is physically incompatible with other drugs including amphotericin B. Flucytosine is well absorbed (75 to 90%) from the gastrointestinal tract. Intake with meals slows the absorption, but does not decrease the amount absorbed. Following an oral dose of 2 grams peak serum levels are reached after approximately 6 hours. The time to peak level decreases with continued therapy. After 4 days peak levels are measured after 2 hours. The drug is eliminated renally. In normal patients flucytosine has reportedly a half-life of 2.5 to 6 hours. In patients with impaired renal function higher serum levels are seen and the drug tends to cumulate in these patients. The drug is mainly excreted unchanged in the urine (90% of an oral dose) and only traces are metabolized and excreted in the feces. Therapeutic serum levels range from 25 to 100 g/ml. Serum levels in excess of 100 ug are associated with a higher incidence of side effects. Periodic measurements of serum levels are recommended for all patients and are a must in patients with renal damage. |
||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Clinical Trial |
|
||||||||||||||||
分子量 |
129.09 |
||||||||||||||||
Formula |
C4H4FN3O |
||||||||||||||||
CAS 号 |
2022-85-7 |
||||||||||||||||
中文名称 |
氟胞嘧啶;5-氟胞嘧啶 |
||||||||||||||||
运输条件 |
Room temperature in continental US; may vary elsewhere. |
||||||||||||||||
储存方式 |
|
||||||||||||||||
溶解性数据 |
In Vitro:
DMSO : 16.67 mg/mL (129.13 mM; Need ultrasonic) H2O : 6.67 mg/mL (51.67 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
|
||||||||||||||||
参考文献 |
|
所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务