SIRT7 inhibitor 97491

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

SIRT7 inhibitor 97491  纯度: 98.05%

SIRT7 inhibitor 97491 是一种有效的 SIRT7 抑制剂，IC50 为 325 nM，SIRT7 inhibitor 97491 降低 SIRT7 去乙酰化酶活性，这种作用存在剂量依赖性。SIRT7 inhibitor 97491 通过在 K373/382 处进行乙酰化来提高 p53 的稳定性，从而防止肿瘤进展。SIRT7 inhibitor 97491 通过 caspase 途径促进凋亡 (apoptosis)。

SIRT7 inhibitor 97491

SIRT7 inhibitor 97491 Chemical Structure

CAS No. : 1807758-81-1

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥4400 In-stock
5 mg ￥4000 In-stock
10 mg ￥6800 In-stock
50 mg ￥19000 In-stock
100 mg ￥29000 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

SIRT7 inhibitor 97491 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Cell Cycle/DNA Damage Compound Library
  • Epigenetics Compound Library
  • Histone Modification Research Compound Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library
  • Antioxidants Compound Library
  • Reprogramming Compound Library
  • Oxygen Sensing Compound Library
  • Glutamine Metabolism Compound Library
  • Targeted Diversity Library

生物活性

SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.[1].

IC50 & Target[1]

SIRT7

325 nM (IC50)

体外研究
(In Vitro)

SIRT7 inhibitor 97491 (1-10 μM) reduces cell growth in MES-SA cells, without causing cytotoxicity in HEK293 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Human uterine sarcoma MES-SA cells
Concentration: 1, 5, 10 μM
Incubation Time: 72 hours
Result: Led to more than 50% decrease in cell proliferation at concentrations of 5 and 10 μM.

Cell Cytotoxicity Assay[1]

Cell Line: Human embryonic kidney cell line HEK293 cells
Concentration: 1, 5, 10 μM
Incubation Time: 24 hours
Result: HEK293 cells were almost unaffected.

体内研究
(In Vivo)

SIRT7 inhibitor 97491 (2 mg/kg; intraperitoneally injected; for 3 weeks, except on weekends) inhibits tumor growth in xenograft mice[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c nude mice (18-20 g; 6-8 weeks old) with MES-SA cells[1]
Dosage: 2 mg/kg
Administration: Intraperitoneally injected; for 3 weeks, except on weekends.
Result: Inhibited cancer growth in vivo.

分子量

285.73

Formula

C15H12ClN3O
CAS 号

1807758-81-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 500 mg/mL (1749.90 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.4998 mL 17.4990 mL 34.9981 mL
5 mM 0.7000 mL 3.4998 mL 6.9996 mL
10 mM 0.3500 mL 1.7499 mL 3.4998 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 4.17 mg/mL (14.59 mM); Clear solution

    此方案可获得 ≥ 4.17 mg/mL (14.59 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 41.7 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Ji-Hye Kim, et al. Identification of a Novel SIRT7 Inhibitor as Anticancer Drug Candidate. Biochem Biophys Res Commun. 2019 Jan 8;508(2):451-457.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

发表回复