SIRT7 inhibitor 97491

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SIRT7 inhibitor 97491  纯度: 98.05%

SIRT7 inhibitor 97491 是一种有效的 SIRT7 抑制剂，IC50 为 325 nM，SIRT7 inhibitor 97491 降低 SIRT7 去乙酰化酶活性，这种作用存在剂量依赖性。SIRT7 inhibitor 97491 通过在 K373/382 处进行乙酰化来提高 p53 的稳定性，从而防止肿瘤进展。SIRT7 inhibitor 97491 通过 caspase 途径促进凋亡 (apoptosis)。

SIRT7 inhibitor 97491

SIRT7 inhibitor 97491 Chemical Structure

CAS No. : 1807758-81-1

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥4400 In-stock
5 mg ￥4000 In-stock
10 mg ￥6800 In-stock
50 mg ￥19000 In-stock
100 mg ￥29000 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

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生物活性

SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.[1].

IC50 & Target[1]

SIRT7

325 nM (IC50)

体外研究
(In Vitro)

SIRT7 inhibitor 97491 (1-10 μM) reduces cell growth in MES-SA cells, without causing cytotoxicity in HEK293 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Human uterine sarcoma MES-SA cells
Concentration: 1, 5, 10 μM
Incubation Time: 72 hours
Result: Led to more than 50% decrease in cell proliferation at concentrations of 5 and 10 μM.

Cell Cytotoxicity Assay[1]

Cell Line: Human embryonic kidney cell line HEK293 cells
Concentration: 1, 5, 10 μM
Incubation Time: 24 hours
Result: HEK293 cells were almost unaffected.

体内研究
(In Vivo)

SIRT7 inhibitor 97491 (2 mg/kg; intraperitoneally injected; for 3 weeks, except on weekends) inhibits tumor growth in xenograft mice[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c nude mice (18-20 g; 6-8 weeks old) with MES-SA cells[1]
Dosage: 2 mg/kg
Administration: Intraperitoneally injected; for 3 weeks, except on weekends.
Result: Inhibited cancer growth in vivo.

分子量

285.73

Formula

C15H12ClN3O
CAS 号

1807758-81-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 500 mg/mL (1749.90 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.4998 mL 17.4990 mL 34.9981 mL
5 mM 0.7000 mL 3.4998 mL 6.9996 mL
10 mM 0.3500 mL 1.7499 mL 3.4998 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 4.17 mg/mL (14.59 mM); Clear solution

    此方案可获得 ≥ 4.17 mg/mL (14.59 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 41.7 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Ji-Hye Kim, et al. Identification of a Novel SIRT7 Inhibitor as Anticancer Drug Candidate. Biochem Biophys Res Commun. 2019 Jan 8;508(2):451-457.

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