SGC3027

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SGC3027  纯度: 98.52%

SGC3027 是一种组蛋白甲基转移酶抑制剂。SGC3027 是第一个有效，选择性，具有细胞活性的 PRMT7 化学探针。

SGC3027

SGC3027 Chemical Structure

CAS No. : 2624313-13-7

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1 mg ￥1400 In-stock
5 mg ￥4900 In-stock
10 mg ￥7850 In-stock
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100 mg   询价  

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SGC3027 相关产品

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生物活性

SGC3027 is a histone methyltransferase inhibitor[1]. SGC3027 is the first potent, selective and cell active chemical probe for PRMT7[2].

IC50 & Target

PRMT7[1][2]
体外研究
(In Vitro)

SGC3027 is a pro-drug of SGC8158 which releases the active component upon reduction in the cell by reductases. In cellular assays using C2C12 cells, SGC3027 inhibits the methylation of HSP70 with IC50=1.3 μM[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

787.37

Formula

C41H47ClN6O6S
CAS 号

2624313-13-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 250 mg/mL (317.51 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2701 mL 6.3503 mL 12.7005 mL
5 mM 0.2540 mL 1.2701 mL 2.5401 mL
10 mM 0.1270 mL 0.6350 mL 1.2701 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Cermakova K, et al. Next-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation. Molecules. 2018 Aug 6;23(8). pii: E1958.

    [2]. SGC3027 for PRMT7.

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