L-2-Hydroxyglutaric acid disodium(Synonyms: (S)-2-Hydroxyglutaric acid disodium)

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L-2-Hydroxyglutaric acid disodium (Synonyms: (S)-2-Hydroxyglutaric acid disodium) 纯度: ≥95.0%

L-2-Hydroxyglutaric acid disodium 是一种表观遗传修饰因子，可用于肾癌的相关研究。L-2-Hydroxyglutaric acid disodium 可抑制组蛋白去甲基化酶 (histone demethylases)，从而促进组蛋白甲基化。L-2-Hydroxyglutaric acid 抑制线粒体肌酸激酶 (Mi-CK) 活性，Km 和 Ki 分别为 2.52 mM 和11.13 mM。

L-2-Hydroxyglutaric acid disodium(Synonyms: (S)-2-Hydroxyglutaric acid disodium)

L-2-Hydroxyglutaric acid disodium Chemical Structure

CAS No. : 63512-50-5

规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥610 In-stock
10 mg ￥550 In-stock
50 mg ￥1650 In-stock
100 mg ￥2250 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

L-2-Hydroxyglutaric acid disodium 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Epigenetics Compound Library
  • Kinase Inhibitor Library
  • Metabolism/Protease Compound Library
  • Stem Cell Signaling Compound Library
  • Histone Modification Research Compound Library
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生物活性

L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2].

体外研究
(In Vitro)

L-2-Hydroxyglutaric acid is potent at inhibiting 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs) including the Ten Eleven Translocation (TET) enzymes[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

192.08

Formula

C5H6Na2O5
CAS 号

63512-50-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

H2O : 83.33 mg/mL (433.83 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.2062 mL 26.0308 mL 52.0616 mL
5 mM 1.0412 mL 5.2062 mL 10.4123 mL
10 mM 0.5206 mL 2.6031 mL 5.2062 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Shim EH, et al. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov. 2014 Nov;4(11):1290-8.

    [2]. da Silva CG, et al. L-2-hydroxyglutaric acid inhibits mitochondrial creatine kinase activity from cerebellum of developing rats. Int J Dev Neurosci. 2003 Jun;21(4):217-24.

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