莫匹罗星
基本信息
产品名称 | 莫匹罗星 |
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英文名称 | Mupirocin |
别名 | 莫匹罗星;假单胞菌酸 |
英文别名 | BRL 4910A;Pseudomonic acid;5,9-Anhydro-2,3,4,8-tetradeoxy-8-[[3-(2-hydroxy-1-methylpropyl)oxiranyl]methyl]-3-methyl-[2E,8[2S,3S(1S,2S)]]-L-talonon-2-enonic acid 8-carboxyoctyl ester |
规格或纯度 | 10mM in DMSO |
运输条件 | 超低温冰袋运输 |
生化机理 | 窄谱抗生素剂。与异亮氨酰t-RNA合成酶结合并抑制蛋白质合成。在体内显示出对革兰氏阳性细菌的剂量依赖性抑菌和杀菌作用。 |
一般描述
Pseudomonic Acid, also known as mupirocin, is an antibiotic isolated from Pseudomonas fluorescens which strongly inhibits protein and RNA synthesis. Inhibition of protein synthesis was reversed by isoleucine and Pseudomonic Acid was shown to inhibit IleRS (isoleucyl-tRNA synthetase) in vitro. Pseudomonic Acid also demonstrates weak inhibitory action on FARSL (phenylalanyl-tRNA synthetase). Efficacy against staphylococci and streptococci including multiply resistant Staphylcoccus aureus and Staphylococcus epidermidis is reported with Pseudomonic Acid.
Product Describtion:
Pseudomonic Acid, also known as mupirocin, is an antibiotic isolated from Pseudomonas fluorescens which strongly inhibits protein and RNA synthesis. Inhibition of protein synthesis was reversed by isoleucine and Pseudomonic Acid was shown to inhibit IleRS (isoleucyl-tRNA synthetase) in vitro. Pseudomonic Acid also demonstrates weak inhibitory action on FARSL (phenylalanyl-tRNA synthetase). Efficacy against staphylococci and streptococci including multiply resistant Staphylcoccus aureus and Staphylococcus epidermidis is reported with Pseudomonic Acid.
An antibiotic inhibitor of isoleucyl-tRNA synthetase
Product Application:
Mupirocin is involved in inhibition of protein synthesis was reversed by isoleucine and Pseudomonic Acid was shown to inhibit IleRS (isoleucyl-tRNA synthetase) in vitro. It also demonstrates weak inhibitory action on FARSL (phenylalanyl-tRNA synthetase). Efficacy against staphylococci and streptococci including multiply resistant Staphylcoccus aureus and Staphylococcus epidermidis is reported with Pseudomonic Acid.
相关属性
CAS编号 | 12650-69-0 |
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敏感性 | 对空气敏感,吸湿 |
比旋光度 | -19° (C=1,MeOH) |
熔点 | 78 °C |
沸点 | 672℃ |
储存温度 | -80℃储存 |
RTECS | RA6907000 |
分子量 | 500.62 |
分子式 | C26H44O9 |
EC号 | 231-791-2 |
品牌 | Jinpan |
PubChem CID | 446596 |