米尔贝霉素A3肟

米尔贝霉素A3肟是一种半合成的大环内酯，是通过对米尔贝霉素A3的混合物进行氧化和肟化而制得的。米尔贝霉素A3肟是市售米尔贝霉素肟的次要成分（约30％），主要用于内寄生虫和外寄生虫感染。像其他米尔贝霉素 / avermectins一样，米尔贝霉素 A3肟的作用是通过打开无脊椎动物神经元中的谷氨酸敏感氯离子通道，导致这些细胞的超极化和信号传递阻滞而导致瘫痪。

Milbemycin A3 oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of a mixture of milbemycin A3. Milbemycin A3 oxime is the minor component (~30%) in the commercial product milbemycin oxime, marketed for endo- and exo-parasite infections. Like the other milbemycin/avermectins, milbemycin A3 oxime acts by opening glutamate sensitive chloride channels in neurons of invertebrates leading to paralysis by hyperpolarisation of these cells and signal transfer blocking.