米尔贝霉素A3

米尔贝霉素A3是一种具有杀螨活性的链霉菌衍生的抗生素。米尔贝霉素是大环内酯家族的一部分，其特征在于由吸水链霉菌产生的螺环环系统，并被建议刺激氯门离子通道。米尔贝霉素A3和A4已用于合成米尔贝霉素α9，α10，α11，α12，α14，α15，α20，α21，α22，α23，α26，α7，δ（2,3），δ（4， 26）-米尔倍霉素A3和A4。

Milbemycin A3 is an antibiotic derived from|Streptomyces|with acaricidal activity. The milbemycins are part of a family of macrocyclic lactones that are characterized by the spiroketal ring system that are produced by|Streptomyces hygroscopicus|subsp.|aureolacrimosus|and are suggested to stimulate chloride-gated ion channels. Milbemycin A3 and A4 have been used to synthesize milbemycins α9, α10, α11, α12, α14, α15, α20, α21, α22, α23, α26, α7, δ(2,3), δ(4,26)-milbemycins A3, and A4.

米尔贝霉素A4肟

米尔贝霉素A4肟是一种半合成的大环内酯，是通过对米尔贝霉素A4的混合物进行氧化和肟化而制得的。米尔贝霉素A4肟是商业产品米尔贝霉素肟的主要成分（约70％），市场上用于内源性和外源性寄生虫感染。像其他milbemycin / avermectins一样，milbemycin A4肟的作用是在无脊椎动物的神经元中打开谷氨酸敏感的氯离子通道，导致这些细胞的超极化和信号传递阻滞而导致瘫痪。

Milbemycin A4 oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of a mixture of milbemycin A4. Milbemycin A4 oxime is the major component (~70%) in the commercial product, milbemycin oxime, marketed for endo- and exo-parasite infections. Like the other milbemycin/avermectins, milbemycin A4 oxime acts by opening glutamate sensitive chloride channels in neurons of invertebrates, leading to paralysis by hyperpolarisation of these cells and signal transfer blocking.

米尔贝霉素A3肟

米尔贝霉素A3肟是一种半合成的大环内酯，是通过对米尔贝霉素A3的混合物进行氧化和肟化而制得的。米尔贝霉素A3肟是市售米尔贝霉素肟的次要成分（约30％），主要用于内寄生虫和外寄生虫感染。像其他米尔贝霉素 / avermectins一样，米尔贝霉素 A3肟的作用是通过打开无脊椎动物神经元中的谷氨酸敏感氯离子通道，导致这些细胞的超极化和信号传递阻滞而导致瘫痪。

Milbemycin A3 oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of a mixture of milbemycin A3. Milbemycin A3 oxime is the minor component (~30%) in the commercial product milbemycin oxime, marketed for endo- and exo-parasite infections. Like the other milbemycin/avermectins, milbemycin A3 oxime acts by opening glutamate sensitive chloride channels in neurons of invertebrates leading to paralysis by hyperpolarisation of these cells and signal transfer blocking.

米尔贝霉素A4

米尔贝霉素A4是一种具有杀螨活性的链霉菌衍生的抗生素。米尔倍霉素是大环内酯家族的一部分，其特征在于由螺链霉菌产生的螺旋环系统，并被认为刺激氯门离子通道。米尔贝霉素A3和A4已用于合成米尔贝霉素α9，α10，α11，α12，α14，α15，α20，α21，α22，α23，α26，α7，δ（2,3），δ（4， 26）-米尔倍霉素A3和A4。

Milbemycin A4 is an antibiotic derived from|Streptomyces|with acaricidal activity. The milbemycins are part of a family of macrocyclic lactones that are characterized by the spiroketal ring system that are produced by|Streptomyces hydroscopious|subsp.|aureolacrimosus|and are suggested to stimulate chloride-gated ion channels. Milbemycin A3 and A4 have been used to synthesize milbemycins α9, α10, α11, α12, α14, α15, α20, α21, α22, α23, α26, α7, δ(2,3), δ(4,26)-milbemycins A3, and A4.