米尔贝霉素A4肟

米尔贝霉素A4肟是一种半合成的大环内酯，是通过对米尔贝霉素A4的混合物进行氧化和肟化而制得的。米尔贝霉素A4肟是商业产品米尔贝霉素肟的主要成分（约70％），市场上用于内源性和外源性寄生虫感染。像其他milbemycin / avermectins一样，milbemycin A4肟的作用是在无脊椎动物的神经元中打开谷氨酸敏感的氯离子通道，导致这些细胞的超极化和信号传递阻滞而导致瘫痪。

Milbemycin A4 oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of a mixture of milbemycin A4. Milbemycin A4 oxime is the major component (~70%) in the commercial product, milbemycin oxime, marketed for endo- and exo-parasite infections. Like the other milbemycin/avermectins, milbemycin A4 oxime acts by opening glutamate sensitive chloride channels in neurons of invertebrates, leading to paralysis by hyperpolarisation of these cells and signal transfer blocking.