Uridine triphosphate(Synonyms: 三磷酸尿苷; UTP; Uridine 5′-triphosphate)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Uridine triphosphate (Synonyms: 三磷酸尿苷; UTP; Uridine 5′-triphosphate) 纯度: ≥98.0%

Uridine triphosphate (UTP;Uridine 5′-triphosphate) 是一种核苷酸,在正常和疾病状态时,调节胰腺内分泌和外分泌、增殖、通道、转运体和细胞内信号传导的功能。

Uridine triphosphate(Synonyms: 三磷酸尿苷; UTP;  Uridine 5

Uridine triphosphate Chemical Structure

CAS No. : 63-39-8

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mg ¥600 In-stock
50 mg ¥1200 In-stock
100 mg ¥1800 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Uridine triphosphate 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus

生物活性

Uridine triphosphate (UTP;Uridine 5′-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Uridine triphosphate treatment induces Schwannoma cell migration through activation of P2Y2 receptors and through the increase of extracellular matrix metalloproteinase-2 (MMP-2) activation and expression[1]. Uridine triphosphate-induced proliferation is mediated by protein kinase D, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, phosphatidylinositol 3-kinase (PI3K), Akt, and phospholipase D. Uridine triphosphate increases phosphorylation of Akt through protein kinase C, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, and PI3K[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Uridine triphosphate reduces mitochondrial calcium levels following hypoxia. Early or late uridine triphosphate preconditioning is effective to reduce infarct size and superior myocardial function[3]. Uridine triphosphate treatment increases the number of monocytes and macrophages infiltrating the pouch and up-regulates the gene expression of IL-4 and IL-13 in the regional lymph nodes[4].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

484.14

Formula

C9H15N2O15P3

CAS 号

63-39-8

中文名称

尿苷三磷酸;三磷酸尿苷;尿苷5′-三磷酸酯;尿苷-5′-三磷酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O : ≥ 150 mg/mL (309.83 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0655 mL 10.3276 mL 20.6552 mL
5 mM 0.4131 mL 2.0655 mL 4.1310 mL
10 mM 0.2066 mL 1.0328 mL 2.0655 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Lamarca A, et al. Uridine 5′-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation. PLoS One. 2014 Jun 6;9(6):e98998.

    [2]. Choi JH, et al. Uridine triphosphate increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor. Pancreas. 2013 May;42(4):680-6.

    [3]. Yitzhaki S, et al. Uridine-5′-triphosphate (UTP) reduces infarct size and improves rat heart function aftermyocardial infarct. Biochem Pharmacol. 2006 Oct 16;72(8):949-55.

    [4]. Iwaki Y, et al. Enhancement of antibody production against rabies virus by uridine 5′-triphosphate in mice. Microbes Infect. 2014 Mar;16(3):196-202.

Cell Assay
[2]

Pancreatic duct epithelial cells are treated with (0.1 μM-1 mM) uridine triphosphate. BrdU is added after different time points (12-24 hours). Proliferation is measured using the BrdU incorporation assay in triplicate[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[3]

Rats: Four main groups are tested: (1) sham without LAD ligation, (2) LAD ligation, (3) injected with UTP (0.44 µg/kg i.v.) 30 min before MI, (4) UTP injection (4.4 µg/kg i.v.) 24 h prior to MI. Several different concentrations of UTP are tested (0.044–44.4 µg/kg). Left ventricular systolic pressure (LVSP), end-diastolic pressure (LVEDP) and heart rates are monitored before, after UTP treatment and post MI[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献
  • [1]. Lamarca A, et al. Uridine 5′-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation. PLoS One. 2014 Jun 6;9(6):e98998.

    [2]. Choi JH, et al. Uridine triphosphate increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor. Pancreas. 2013 May;42(4):680-6.

    [3]. Yitzhaki S, et al. Uridine-5′-triphosphate (UTP) reduces infarct size and improves rat heart function aftermyocardial infarct. Biochem Pharmacol. 2006 Oct 16;72(8):949-55.

    [4]. Iwaki Y, et al. Enhancement of antibody production against rabies virus by uridine 5′-triphosphate in mice. Microbes Infect. 2014 Mar;16(3):196-202.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

发表回复