标签归档：triphosphate

Deoxythymidine-5′-triphosphate-13C10,15N2 disodium

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Deoxythymidine-5′-triphosphate-13C10,15N2 disodium 

Deoxythymidine-5′-triphosphate-13C10,15N2 disodium 是一种 13C 和 15N 标记的 Deoxythymidine-5′-triphosphate。Deoxythymidine-5′-triphosphate (dTTP)，一种三磷酸核苷，可用于 DNA 的合成。

Deoxythymidine-5

Deoxythymidine-5′-triphosphate-13C10,15N2 disodium Chemical Structure

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生物活性

Deoxythymidine-5′-triphosphate-13C10,15N2 disodium is the 13C-labeled and 15N-labeled Deoxythymidine-5′-triphosphate. Deoxythymidine-5′-triphosphate (dTTP) is one of the four nucleoside triphosphates. Deoxythymidine-5′-triphosphate (dTTP) is used in the synthesis of DNA[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

538.05

Formula

13C10H1515N2Na2O14P3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Tattersall MH, et al. Deoxyribonucleoside triphosphates in human cells: changes in disease and following exposure to drugs. Eur J Clin Invest. 1975;5(2):191-202.

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Cytidine-5′-triphosphate(Synonyms: Cytidine triphosphate; 5′-CTP)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Cytidine-5′-triphosphate (Synonyms: Cytidine triphosphate; 5′-CTP) 纯度: ≥98.0%

Cytidine 5′-triphosphate (Cytidine triphosphate; 5′-CTP) 是一种三磷酸核苷，作为核苷酸和核酸、脂质生物合成的构建砌块。胞嘧啶核苷三磷酸合酶可以催化 UTP 生成 5′-CTP。Cytidine 5′-triphosphate 是 T. gondii 在从头嘧啶生物合成通路中必不可少的生物分子。

Cytidine-5

Cytidine-5′-triphosphate Chemical Structure

CAS No. : 65-47-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in Water ￥550 In-stock
100 mg ￥500 In-stock
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Cytidine-5′-triphosphate 相关产品

•相关化合物库:

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生物活性

Cytidine 5′-triphosphate (Cytidine triphosphate; 5′-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii[1].

分子量

483.16

Formula

C9H16N3O14P3
CAS 号

65-47-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

H2O : 83.33 mg/mL (172.47 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0697 mL 10.3485 mL 20.6971 mL
5 mM 0.4139 mL 2.0697 mL 4.1394 mL
10 mM 0.2070 mL 1.0349 mL 2.0697 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Heidy Y Narvaez-Ortiz, et al. A CTP Synthase Undergoing Stage-Specific Spatial Expression Is Essential for the Survival of the Intracellular Parasite Toxoplasma gondii. Front Cell Infect Microbiol. 2018 Mar 22;8:83.

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Deoxythymidine-5′-triphosphate(Synonyms: dTTP)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Deoxythymidine-5′-triphosphate (Synonyms: dTTP)

Deoxythymidine-5′-triphosphate (dTTP)，一种三磷酸核苷，可用于 DNA 的合成。

Deoxythymidine-5

Deoxythymidine-5′-triphosphate Chemical Structure

CAS No. : 365-08-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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Deoxythymidine-5′-triphosphate 的其他形式现货产品:

Deoxythymidine-5′-triphosphate trisodium

生物活性

Deoxythymidine-5′-triphosphate (dTTP) is one of the four nucleoside triphosphates. Deoxythymidine-5′-triphosphate (dTTP) is used in the synthesis of DNA[1].

IC50 & Target

Human Endogenous Metabolite

 

Clinical Trial

分子量

482.17

Formula

C10H17N2O14P3
CAS 号

365-08-2
中文名称

脱氧胸苷三磷酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tattersall MH, et al. Deoxyribonucleoside triphosphates in human cells: changes in disease and following exposure to drugs. Eur J Clin Invest. 1975;5(2):191-202.

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dGTP(Synonyms: 2′-Deoxyguanosine-5′-triphosphate)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

dGTP (Synonyms: 2′-Deoxyguanosine-5′-triphosphate)

dGTP (2′-Deoxyguanosine-5′-triphosphate) 是一种鸟苷核苷酸，可用于脱氧核糖核酸的合成。鸟苷核苷酸 (GDP, GTP, dGDP, dGTP) 对 8-O-GDP (8-O-GDP)、8-O-dGTP、8-O-GTP 和 8-O-dGTP 的氧化损伤高度敏感。

dGTP(Synonyms: 2

dGTP Chemical Structure

CAS No. : 2564-35-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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dGTP 的其他形式现货产品:

Deoxyguanosine triphosphate trisodium salt

生物活性

dGTP (2′-Deoxyguanosine-5′-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP[1].

分子量

507.18

Formula

C10H16N5O13P3
CAS 号

2564-35-4
中文名称

2′-脱氧鸟苷-5′-三磷酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kapoor I, et al. Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli. J Bacteriol. 2019;202(1):e00567-19. Published 2019 Dec 6.

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dGTP(Synonyms: 2′-Deoxyguanosine-5′-triphosphate)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

dGTP (Synonyms: 2′-Deoxyguanosine-5′-triphosphate)

dGTP (2′-Deoxyguanosine-5′-triphosphate) 是一种鸟苷核苷酸，可用于脱氧核糖核酸的合成。鸟苷核苷酸 (GDP, GTP, dGDP, dGTP) 对 8-O-GDP (8-O-GDP)、8-O-dGTP、8-O-GTP 和 8-O-dGTP 的氧化损伤高度敏感。

dGTP(Synonyms: 2

dGTP Chemical Structure

CAS No. : 2564-35-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

dGTP 的其他形式现货产品:

Deoxyguanosine triphosphate trisodium salt

生物活性

dGTP (2′-Deoxyguanosine-5′-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP[1].

分子量

507.18

Formula

C10H16N5O13P3
CAS 号

2564-35-4
中文名称

2′-脱氧鸟苷-5′-三磷酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kapoor I, et al. Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli. J Bacteriol. 2019;202(1):e00567-19. Published 2019 Dec 6.

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Deoxythymidine-5′-triphosphate(Synonyms: dTTP)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Deoxythymidine-5′-triphosphate (Synonyms: dTTP)

Deoxythymidine-5′-triphosphate (dTTP)，一种三磷酸核苷，可用于 DNA 的合成。

Deoxythymidine-5

Deoxythymidine-5′-triphosphate Chemical Structure

CAS No. : 365-08-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Deoxythymidine-5′-triphosphate 的其他形式现货产品:

Deoxythymidine-5′-triphosphate trisodium

生物活性

Deoxythymidine-5′-triphosphate (dTTP) is one of the four nucleoside triphosphates. Deoxythymidine-5′-triphosphate (dTTP) is used in the synthesis of DNA[1].

IC50 & Target

Human Endogenous Metabolite

 

Clinical Trial

分子量

482.17

Formula

C10H17N2O14P3
CAS 号

365-08-2
中文名称

脱氧胸苷三磷酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tattersall MH, et al. Deoxyribonucleoside triphosphates in human cells: changes in disease and following exposure to drugs. Eur J Clin Invest. 1975;5(2):191-202.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

dGTP(Synonyms: 2′-Deoxyguanosine-5′-triphosphate)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

dGTP (Synonyms: 2′-Deoxyguanosine-5′-triphosphate)

dGTP (2′-Deoxyguanosine-5′-triphosphate) 是一种鸟苷核苷酸，可用于脱氧核糖核酸的合成。鸟苷核苷酸 (GDP, GTP, dGDP, dGTP) 对 8-O-GDP (8-O-GDP)、8-O-dGTP、8-O-GTP 和 8-O-dGTP 的氧化损伤高度敏感。

dGTP(Synonyms: 2

dGTP Chemical Structure

CAS No. : 2564-35-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

dGTP 的其他形式现货产品:

Deoxyguanosine triphosphate trisodium salt

生物活性

dGTP (2′-Deoxyguanosine-5′-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP[1].

分子量

507.18

Formula

C10H16N5O13P3
CAS 号

2564-35-4
中文名称

2′-脱氧鸟苷-5′-三磷酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kapoor I, et al. Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli. J Bacteriol. 2019;202(1):e00567-19. Published 2019 Dec 6.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Thio-ITP(Synonyms: 6-Thioinosine 5′-triphosphate; 6-Mercaptopurine-riboside-5′-triphosphate; 6-Thio-ITP)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Thio-ITP (Synonyms: 6-Thioinosine 5′-triphosphate; 6-Mercaptopurine-riboside-5′-triphosphate; 6-Thio-ITP)

Thio-ITP (6-Thioinosine 5′-triphosphate) 是一种 RNA 聚合酶 (RNA polymerase) 活性的竞争性抑制剂。Thio-ITP 对聚合酶具有高表观亲和力，RNA 聚合酶 I 的 Ki 值为 40.9 μM，RNA聚合酶 II 的 Ki 值为 38.0 μM。

Thio-ITP(Synonyms: 6-Thioinosine 5′-triphosphate; 6-Mercaptopurine-riboside-5

Thio-ITP Chemical Structure

CAS No. : 27652-34-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Thio-ITP (6-Thioinosine 5′-triphosphate) is an RNA polymerase activity competitive inhibitor. Thio-ITP has a high apparent affinity for the polymerases (RNA polymerase I Ki: 40.9 μM; RNA polymerase II Ki: 38.0 μM)[1].

IC50 & Target[1]

RNA polymerase I

40.9±11.0 μM (Ki)

RNA polymerase II

38.0±6.47 μM (Ki)

体外研究
(In Vitro)

Thio-ITP inhibits both endogenous and exogenous DNA-directed RNA synthesis[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

524.23

Formula

C10H15N4O13P3S
CAS 号

27652-34-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kawahata RT, Chuang LF, Holmberg CA, Osburn BI, Chuang RY. Inhibition of human lymphoma DNA-dependent RNA polymerase activity by 6-mercaptopurine ribonucleoside triphosphate. Cancer Res. 1983 Aug;43(8):3655-9.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Thio-ITP(Synonyms: 6-Thioinosine 5′-triphosphate; 6-Mercaptopurine-riboside-5′-triphosphate; 6-Thio-ITP)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Thio-ITP (Synonyms: 6-Thioinosine 5′-triphosphate; 6-Mercaptopurine-riboside-5′-triphosphate; 6-Thio-ITP)

Thio-ITP (6-Thioinosine 5′-triphosphate) 是一种 RNA 聚合酶 (RNA polymerase) 活性的竞争性抑制剂。Thio-ITP 对聚合酶具有高表观亲和力，RNA 聚合酶 I 的 Ki 值为 40.9 μM，RNA聚合酶 II 的 Ki 值为 38.0 μM。

Thio-ITP(Synonyms: 6-Thioinosine 5′-triphosphate; 6-Mercaptopurine-riboside-5

Thio-ITP Chemical Structure

CAS No. : 27652-34-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Thio-ITP (6-Thioinosine 5′-triphosphate) is an RNA polymerase activity competitive inhibitor. Thio-ITP has a high apparent affinity for the polymerases (RNA polymerase I Ki: 40.9 μM; RNA polymerase II Ki: 38.0 μM)[1].

IC50 & Target[1]

RNA polymerase I

40.9±11.0 μM (Ki)

RNA polymerase II

38.0±6.47 μM (Ki)

体外研究
(In Vitro)

Thio-ITP inhibits both endogenous and exogenous DNA-directed RNA synthesis[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

524.23

Formula

C10H15N4O13P3S
CAS 号

27652-34-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kawahata RT, Chuang LF, Holmberg CA, Osburn BI, Chuang RY. Inhibition of human lymphoma DNA-dependent RNA polymerase activity by 6-mercaptopurine ribonucleoside triphosphate. Cancer Res. 1983 Aug;43(8):3655-9.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Thio-ITP(Synonyms: 6-Thioinosine 5′-triphosphate; 6-Mercaptopurine-riboside-5′-triphosphate; 6-Thio-ITP)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Thio-ITP (Synonyms: 6-Thioinosine 5′-triphosphate; 6-Mercaptopurine-riboside-5′-triphosphate; 6-Thio-ITP)

Thio-ITP (6-Thioinosine 5′-triphosphate) 是一种 RNA 聚合酶 (RNA polymerase) 活性的竞争性抑制剂。Thio-ITP 对聚合酶具有高表观亲和力，RNA 聚合酶 I 的 Ki 值为 40.9 μM，RNA聚合酶 II 的 Ki 值为 38.0 μM。

Thio-ITP(Synonyms: 6-Thioinosine 5′-triphosphate; 6-Mercaptopurine-riboside-5

Thio-ITP Chemical Structure

CAS No. : 27652-34-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Thio-ITP (6-Thioinosine 5′-triphosphate) is an RNA polymerase activity competitive inhibitor. Thio-ITP has a high apparent affinity for the polymerases (RNA polymerase I Ki: 40.9 μM; RNA polymerase II Ki: 38.0 μM)[1].

IC50 & Target[1]

RNA polymerase I

40.9±11.0 μM (Ki)

RNA polymerase II

38.0±6.47 μM (Ki)

体外研究
(In Vitro)

Thio-ITP inhibits both endogenous and exogenous DNA-directed RNA synthesis[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

524.23

Formula

C10H15N4O13P3S
CAS 号

27652-34-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kawahata RT, Chuang LF, Holmberg CA, Osburn BI, Chuang RY. Inhibition of human lymphoma DNA-dependent RNA polymerase activity by 6-mercaptopurine ribonucleoside triphosphate. Cancer Res. 1983 Aug;43(8):3655-9.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Cytarabine triphosphate(Synonyms: Ara-CTP)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Cytarabine triphosphate (Synonyms: Ara-CTP)

Cytarabine triphosphate (Ara-CTP)，一种 Cytarabine 的活性代谢物，是 DNA 合成的竞争性抑制剂。细胞内 Cytarabine triphosphate 水平可用于预测白血病母细胞对 Cytarabine 的化学敏感性。

Cytarabine triphosphate(Synonyms: Ara-CTP)

Cytarabine triphosphate Chemical Structure

CAS No. : 13191-15-6

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生物活性

Cytarabine triphosphate (Ara-CTP), an active metabolite of Cytarabine, is a competitive inhibitor of DNA synthesis. Intracellular Cytarabine triphosphate levels can be used to predict chemosensitivity of leukemic blasts to Cytarabine[1].

分子量

483.16

Formula

C9H16N3O14P3
CAS 号

13191-15-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Anderson E, et, al. Intracellular cytarabine triphosphate in circulating blasts post-treatment predicts remission status in patients with acute myeloid leukemia. Exp Hematol. 2019 Jun;74:13-18.e3.

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Cytarabine triphosphate(Synonyms: Ara-CTP)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Cytarabine triphosphate (Synonyms: Ara-CTP)

Cytarabine triphosphate (Ara-CTP)，一种 Cytarabine 的活性代谢物，是 DNA 合成的竞争性抑制剂。细胞内 Cytarabine triphosphate 水平可用于预测白血病母细胞对 Cytarabine 的化学敏感性。

Cytarabine triphosphate(Synonyms: Ara-CTP)

Cytarabine triphosphate Chemical Structure

CAS No. : 13191-15-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

Cytarabine triphosphate (Ara-CTP), an active metabolite of Cytarabine, is a competitive inhibitor of DNA synthesis. Intracellular Cytarabine triphosphate levels can be used to predict chemosensitivity of leukemic blasts to Cytarabine[1].

分子量

483.16

Formula

C9H16N3O14P3
CAS 号

13191-15-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Anderson E, et, al. Intracellular cytarabine triphosphate in circulating blasts post-treatment predicts remission status in patients with acute myeloid leukemia. Exp Hematol. 2019 Jun;74:13-18.e3.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Cytarabine triphosphate(Synonyms: Ara-CTP)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Cytarabine triphosphate (Synonyms: Ara-CTP)

Cytarabine triphosphate (Ara-CTP)，一种 Cytarabine 的活性代谢物，是 DNA 合成的竞争性抑制剂。细胞内 Cytarabine triphosphate 水平可用于预测白血病母细胞对 Cytarabine 的化学敏感性。

Cytarabine triphosphate(Synonyms: Ara-CTP)

Cytarabine triphosphate Chemical Structure

CAS No. : 13191-15-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Cytarabine triphosphate (Ara-CTP), an active metabolite of Cytarabine, is a competitive inhibitor of DNA synthesis. Intracellular Cytarabine triphosphate levels can be used to predict chemosensitivity of leukemic blasts to Cytarabine[1].

分子量

483.16

Formula

C9H16N3O14P3
CAS 号

13191-15-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Anderson E, et, al. Intracellular cytarabine triphosphate in circulating blasts post-treatment predicts remission status in patients with acute myeloid leukemia. Exp Hematol. 2019 Jun;74:13-18.e3.

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Uridine triphosphate(Synonyms: 三磷酸尿苷; UTP; Uridine 5′-triphosphate)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Uridine triphosphate (Synonyms: 三磷酸尿苷; UTP; Uridine 5′-triphosphate) 纯度: ≥98.0%

Uridine triphosphate (UTP;Uridine 5′-triphosphate) 是一种核苷酸，在正常和疾病状态时，调节胰腺内分泌和外分泌、增殖、通道、转运体和细胞内信号传导的功能。

Uridine triphosphate(Synonyms: 三磷酸尿苷; UTP; Uridine 5

Uridine triphosphate Chemical Structure

CAS No. : 63-39-8

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50 mg ￥1200 In-stock
100 mg ￥1800 In-stock
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Uridine triphosphate 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus

生物活性

Uridine triphosphate (UTP;Uridine 5′-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Uridine triphosphate treatment induces Schwannoma cell migration through activation of P2Y2 receptors and through the increase of extracellular matrix metalloproteinase-2 (MMP-2) activation and expression[1]. Uridine triphosphate-induced proliferation is mediated by protein kinase D, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, phosphatidylinositol 3-kinase (PI3K), Akt, and phospholipase D. Uridine triphosphate increases phosphorylation of Akt through protein kinase C, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, and PI3K[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Uridine triphosphate reduces mitochondrial calcium levels following hypoxia. Early or late uridine triphosphate preconditioning is effective to reduce infarct size and superior myocardial function[3]. Uridine triphosphate treatment increases the number of monocytes and macrophages infiltrating the pouch and up-regulates the gene expression of IL-4 and IL-13 in the regional lymph nodes[4].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

484.14

Formula

C9H15N2O15P3
CAS 号

63-39-8
中文名称

尿苷三磷酸；三磷酸尿苷；尿苷5′-三磷酸酯；尿苷-5′-三磷酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O : ≥ 150 mg/mL (309.83 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0655 mL 10.3276 mL 20.6552 mL
5 mM 0.4131 mL 2.0655 mL 4.1310 mL
10 mM 0.2066 mL 1.0328 mL 2.0655 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Lamarca A, et al. Uridine 5′-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation. PLoS One. 2014 Jun 6;9(6):e98998.

    [2]. Choi JH, et al. Uridine triphosphate increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor. Pancreas. 2013 May;42(4):680-6.

    [3]. Yitzhaki S, et al. Uridine-5′-triphosphate (UTP) reduces infarct size and improves rat heart function aftermyocardial infarct. Biochem Pharmacol. 2006 Oct 16;72(8):949-55.

    [4]. Iwaki Y, et al. Enhancement of antibody production against rabies virus by uridine 5′-triphosphate in mice. Microbes Infect. 2014 Mar;16(3):196-202.
Cell Assay
[2]

Pancreatic duct epithelial cells are treated with (0.1 μM-1 mM) uridine triphosphate. BrdU is added after different time points (12-24 hours). Proliferation is measured using the BrdU incorporation assay in triplicate[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[3]

Rats: Four main groups are tested: (1) sham without LAD ligation, (2) LAD ligation, (3) injected with UTP (0.44 µg/kg i.v.) 30 min before MI, (4) UTP injection (4.4 µg/kg i.v.) 24 h prior to MI. Several different concentrations of UTP are tested (0.044–44.4 µg/kg). Left ventricular systolic pressure (LVSP), end-diastolic pressure (LVEDP) and heart rates are monitored before, after UTP treatment and post MI[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Lamarca A, et al. Uridine 5′-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation. PLoS One. 2014 Jun 6;9(6):e98998.

    [2]. Choi JH, et al. Uridine triphosphate increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor. Pancreas. 2013 May;42(4):680-6.

    [3]. Yitzhaki S, et al. Uridine-5′-triphosphate (UTP) reduces infarct size and improves rat heart function aftermyocardial infarct. Biochem Pharmacol. 2006 Oct 16;72(8):949-55.

    [4]. Iwaki Y, et al. Enhancement of antibody production against rabies virus by uridine 5′-triphosphate in mice. Microbes Infect. 2014 Mar;16(3):196-202.

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Fludarabine triphosphate(Synonyms: F-ara-ATP)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Fludarabine triphosphate (Synonyms: F-ara-ATP)

Fludarabine triphosphate (F-ara-ATP) 是Fludarabine phosphate (HY-B0028) 的细胞毒性代谢物，抑制核糖核苷酸还原酶和 DNA 聚合酶，最终导致细胞凋亡。

Fludarabine triphosphate(Synonyms: F-ara-ATP)

Fludarabine triphosphate Chemical Structure

CAS No. : 74832-57-8

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生物活性

Fludarabine triphosphate (F-ara-ATP), the cytotoxic metabolite of Fludarabine phosphate (HY-B0028), inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis[1].

分子量

525.17

Formula

C10H15FN5O13P3
CAS 号

74832-57-8
中文名称

三磷酸氟达拉滨
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Erica L. Woodahl, et al. A NOVEL PHENOTYPIC METHOD TO DETERMINE FLUDARABINE TRIPHOSPHATE ACCUMULATION IN T-LYMPHOCYTES FROM HEMATOPOIETIC CELL TRANSPLANTATION PATIENTS. J Cell Mol Med. 2020 Jul 31.

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Guanosine triphosphate(Synonyms: GTP)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Guanosine triphosphate (Synonyms: GTP)

Guanosine triphosphate 是一种天然核苷酸。GTP 衍生物可作为抗 COVID-19 的特异性抑制剂。

Guanosine triphosphate(Synonyms: GTP)

Guanosine triphosphate Chemical Structure

CAS No. : 86-01-1

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Guanosine triphosphate 的其他形式现货产品:

Guanosine-5′-triphosphate disodium salt

生物活性

Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19[1].

IC50 & Target

Human Endogenous Metabolite

 

分子量

523.18

Formula

C10H16N5O14P3
CAS 号

86-01-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Abdo A Elfiky, et al. Anti-HCV, nucleotide inhibitors, repurposing against COVID-19. Life Sci. 2020 May 1;248:117477.

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