Impurity F of Calcipotriol

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Impurity F of Calcipotriol  纯度: 99.40%

Impurity F of Calcipotriol是钙泊三醇的杂质，钙泊三醇是1,25-Dihydroxyvitamin D3类似物。

Impurity F of Calcipotriol

Impurity F of Calcipotriol Chemical Structure

CAS No. : 112875-61-3

规格 价格 是否有货 数量
1 mg ￥9207 In-stock
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生物活性

Impurity F of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors. IC50 value: Target: Vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; Calcipotriol (MC 903; Calcipotriene) exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.

分子量

641.13

Formula

C39H68O3Si2
CAS 号

112875-61-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light, stored under nitrogen

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参考文献

  • [1]. Binderup (1993) Comparison of calcipotriol with selected metabolites and analogues of vitamin D3: effects on cell growth regulation in vitro and calcium metabolism in vivo. Pharmacol.Toxicol. 72 240.

    [2]. Knutson et al (1997) Pharmacokinetics and systemic effect on calcium homeostasis of 1a,24-dihydroxyvitamin D2 in rats. Biochem.Pharmacol. 53 829.

    [3]. Wietrzyk et al (2007) Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anticancer Drugs 18 447.111

    [4]. Lise Binderup,, Erik Bramm. Effects of a novel vitamin D analogue MC 903 on cell proliferation and differentiation in vitro and on calcium metabolism in vivo. Biochemical Pharmacology. Volume 37, Issue 5, 1 March 1988, Pages 889-895

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