NH2-PEG4-CH2CH2COOH(Synonyms: 1-氨基-3,6,9,12-四氧代十五烷-15-酸)

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NH2-PEG4-CH2CH2COOH (Synonyms: 1-氨基-3,6,9,12-四氧代十五烷-15-酸) 纯度: ≥98.0%

NH2-PEG4-CH2CH2COOH 是一种可降解 (cleavable) 的 4 单元 PEG 类 ADC linker,用于抗体偶联药物 (ADC) 的合成。NH2-PEG4-CH2CH2COOH 也是一种基于 PEG 的 PROTAC linker,可用于 PROTAC 的合成。

NH2-PEG4-CH2CH2COOH(Synonyms: 1-氨基-3,6,9,12-四氧代十五烷-15-酸)

NH2-PEG4-CH2CH2COOH Chemical Structure

CAS No. : 663921-15-1

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生物活性

NH2-PEG4-CH2CH2COOH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH2-PEG4-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

IC50 & Target

Cleavable

 

PEGs

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

265.30

Formula

C11H23NO6

CAS 号

663921-15-1

中文名称

1-氨基-3,6,9,12-四氧代十五烷-15-酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献
  • [1]. Hans-Georg Lerchen, et al. Antibody drug conjugates (adcs) having enzymatically cleavable groups. WO2018114578A1.

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