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NCGC00247743 纯度: 96.17%
NCGC00247743 是一种组蛋白赖氨酸脱甲基酶 KDM4 抑制剂。
NCGC00247743 Chemical Structure
CAS No. : 1435192-04-3
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥5500 | In-stock | |
10 mg | ¥8500 | In-stock | |
25 mg | ¥16000 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
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NCGC00247743 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Epigenetics Compound Library
- Histone Modification Research Compound Library
- Anti-Cancer Compound Library
生物活性 |
NCGC00247743 is a histone lysine demethylase KDM4 inhibitor. |
IC50 & Target |
KDM4[1] |
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体外研究 (In Vitro) |
Based on structure-activity relationship studies, a series of chemical compounds are derived from 8-hydroxyquinoline (8HQ) and shown to be active inhibitors of KDM4E and KDM4A. The effect of these compounds is tested on the growth of LNCaP cells and NCGC00247751 (A1), NCGC00244536 (B3), and NCGC00247743 (I9) are selected. These inhibitors inhibit LNCaP cell growth with IC50s in the μM range. These compounds also inhibit the enzymatic activity of other KDM4 isoforms although, interestingly, the potency and efficacy of B3 and A1 for KDM4A, 4C, and 4D are lower compared to that of NCGC00247743 (I9), suggesting a potential selectivity of the inhibitors for different isoforms of KDM4[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
391.51 |
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Formula |
C24H29N3O2 |
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CAS 号 |
1435192-04-3 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 62.5 mg/mL (159.64 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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