Nonactin(Synonyms: 无活菌素; Ammonium ionophore I)

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Nonactin (Synonyms: 无活菌素; Ammonium ionophore I) 纯度: ≥95.0%

Nonactin 来源于 Streptomyces griseus， 是一种抗生素，作为 K+ 和 NH4+ 载体。Nonactin 是一种氧化磷酸化 (OXPHOS) 解偶联剂。Nonactin 选择性诱导含突变 β-catenin 的细胞凋亡。Nonactin 抑制内源性 HSP60 表面表达。

Nonactin(Synonyms: 无活菌素; Ammonium ionophore I)

Nonactin Chemical Structure

CAS No. : 6833-84-7

规格 价格 是否有货 数量
1 mg ￥1650 In-stock
5 mg ￥4500 In-stock
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Nonactin 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Macrocyclic Compound Library

生物活性

Nonactin is a naturally occurring macrotetrolide antibiotic from Streptomyces griseus. Nonactin acts as an ionophore for monovalent cations, including K+, and NH4+[1]. Nonactin is able to uncouple the oxidative phosphorylation (OXPHOS) of mitochondria. Nonactin selectively induces apoptosis in cell lines harboring active mutant β-catenin[2]. Nonactin inhibits the surface expression of endogenous HSP60[3].

分子量

736.93

Formula

C40H64O12
CAS 号

6833-84-7
中文名称

无活菌素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Martínez-Haya B, et al. On the ionophoric selectivity of nonactin and related macrotetrolide derivatives. Phys Chem Chem Phys. 2017 Jan 4;19(2):1288-1297.

    [2]. Shikata Y, et al. Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells. Cancer Sci. 2017 Apr;108(4):772-784.

    [3]. Barazi HO, et al. Identification of heat shock protein 60 as a molecular mediator of alpha 3 beta 1 integrin activation. Cancer Res. 2002 Mar 1;62(5):1541-8.

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