Mal-PEG2-VCP-Eribulin

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Mal-PEG2-VCP-Eribulin 

Mal-PEG2-VCP-Eribulin 由 ADC linker (Mal-PEG2-VCP) 和 Eribulin 偶联而成。Eribulin 是一种独特的微管 (microtubule) 抑制剂，具有抗肿瘤活性。Mal-PEG2-VCP-Eribulin 可用于偶联抗体。

Mal-PEG2-VCP-Eribulin

Mal-PEG2-VCP-Eribulin Chemical Structure

CAS No. : 2130869-18-8

规格 价格 是否有货 数量
1 mg ￥25000 In-stock
5 mg ￥85000 In-stock
10 mg   询价  
50 mg   询价  

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生物活性

Mal-PEG2-VCP-Eribulin consists the ADCs linker (Mal-PEG2-VCP) and Eribulin[1]. Eribulin is a mechanistically unique microtubule inhibitor for cancer[2]. Mal-PEG2-VCP-Eribulin is an Eribulin-based drug for antibody conjugates[1].

IC50 & Target

Traditional Cytotoxic Agents

 

分子量

1374.57

Formula

C70H99N7O21
CAS 号

2130869-18-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
参考文献

  • [1]. Earl F Albone, et al. Eribulin-based antibody-drug conjugates and methods of use. US20170252458A1.

    [2]. Towle MJ, et al. Eribulin induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions. Cancer Res. 2011 Jan 15;71(2):496-505.

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