Mal-PEG4-VA-PBD

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Mal-PEG4-VA-PBD 

Mal-PEG4-VA-PBD 是一种抗体偶联药物,由抗肿瘤抗生素 Pyrrolobenzodiazepine (PBD) 和 Mal-PEG4-VA 连接而成。

Mal-PEG4-VA-PBD

Mal-PEG4-VA-PBD Chemical Structure

CAS No. : 1342820-68-1

规格 价格 是否有货
1 mg ¥57500 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Mal-PEG4-VA-PBD is a drug-linker conjugate for ADC by using the antitumor antibiotic, Pyrrolobenzodiazepine (PBD), linked via Mal-PEG4-VA.

IC50 & Target

Pyrrolobenzodiazepines

 

分子量

1294.40

Formula

C68H79N9O17

CAS 号

1342820-68-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Maleimide PEG Maleimide, MAL-PEG-MAL Cat. No. PG2-ML-5k 5000 Da 100 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Maleimide PEG Maleimide, MAL-PEG-MAL

Cat. No. PG2-ML-5k Maleimide PEG Maleimide, MAL-PEG-MAL           Cat. No. PG2-ML-5k     5000 Da    100 mg
Specification 5000 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Maleimide functionalized polyethylene glycol, Maleimide PEG is a sulfhydryl (thiol/SH) group reactive PEG derivative that can be used to selectively modify protein, peptide or any other surfaces with availablesulfhydryl groups. The reaction between maleimide and thiol proceeds readily at pH 6.5~7.5 to form stable thioether bonds.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated. Avoid frequent thaw and freeze.

Reaction Procedures:

Generally, a 10- to 20-fold molar excess of Maleimide PEG over the amount of thiol-containing material results in sufficient conjugation.

Materials Required:

  • Pegylation buffer, PBS buffer, pH 7 or other thiol-free buffer at pH 7.
  • Maleimide stock solution: 100 mg in 1 mL conjugation buffer.
  • Washing solution: Distilled water or any aqueous buffer.

Reaction Steps:

Dissolve targeted materials in conjugation buffer. Estimate the concentration thiol groups on the targeted materials. Add maleimide PEG stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. 10~50 molar excess of PEG maleimide needed for optimal conjugation; Allow mixture agitates at room temperature for 2~4 hours at room temperature or overnight at 4 0C.Conjugate can be purified either by size exclusion chromatography or dialysis.

Documents
  • SDS
  • DataSheet

Maleimide PEG Maleimide, MAL-PEG-MAL Cat. No. PG2-ML-3k 3400 Da 100 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Maleimide PEG Maleimide, MAL-PEG-MAL

Cat. No. PG2-ML-3k Maleimide PEG Maleimide, MAL-PEG-MAL           Cat. No. PG2-ML-3k     3400 Da    100 mg
Specification 3400 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Maleimide functionalized polyethylene glycol, Maleimide PEG is a sulfhydryl (thiol/SH) group reactive PEG derivative that can be used to selectively modify protein, peptide or any other surfaces with availablesulfhydryl groups. The reaction between maleimide and thiol proceeds readily at pH 6.5~7.5 to form stable thioether bonds.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated. Avoid frequent thaw and freeze.

Reaction Procedures:

Generally, a 10- to 20-fold molar excess of Maleimide PEG over the amount of thiol-containing material results in sufficient conjugation.

Materials Required:

  • Pegylation buffer, PBS buffer, pH 7 or other thiol-free buffer at pH 7.
  • Maleimide stock solution: 100 mg in 1 mL conjugation buffer.
  • Washing solution: Distilled water or any aqueous buffer.

Reaction Steps:

Dissolve targeted materials in conjugation buffer. Estimate the concentration thiol groups on the targeted materials. Add maleimide PEG stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. 10~50 molar excess of PEG maleimide needed for optimal conjugation; Allow mixture agitates at room temperature for 2~4 hours at room temperature or overnight at 4 0C.Conjugate can be purified either by size exclusion chromatography or dialysis.

Documents
  • SDS
  • DataSheet

Maleimide PEG Maleimide, MAL-PEG-MAL Cat. No. PG2-ML-2k 2000 Da 100 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Maleimide PEG Maleimide, MAL-PEG-MAL

Cat. No. PG2-ML-2k Maleimide PEG Maleimide, MAL-PEG-MAL           Cat. No. PG2-ML-2k     2000 Da    100 mg
Specification 2000 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Maleimide functionalized polyethylene glycol, Maleimide PEG is a sulfhydryl (thiol/SH) group reactive PEG derivative that can be used to selectively modify protein, peptide or any other surfaces with availablesulfhydryl groups. The reaction between maleimide and thiol proceeds readily at pH 6.5~7.5 to form stable thioether bonds.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated. Avoid frequent thaw and freeze.

Reaction Procedures:

Generally, a 10- to 20-fold molar excess of Maleimide PEG over the amount of thiol-containing material results in sufficient conjugation.

Materials Required:

  • Pegylation buffer, PBS buffer, pH 7 or other thiol-free buffer at pH 7.
  • Maleimide stock solution: 100 mg in 1 mL conjugation buffer.
  • Washing solution: Distilled water or any aqueous buffer.

Reaction Steps:

Dissolve targeted materials in conjugation buffer. Estimate the concentration thiol groups on the targeted materials. Add maleimide PEG stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. 10~50 molar excess of PEG maleimide needed for optimal conjugation; Allow mixture agitates at room temperature for 2~4 hours at room temperature or overnight at 4 0C.Conjugate can be purified either by size exclusion chromatography or dialysis.

Documents
  • SDS
  • DataSheet

Maleimide PEG Maleimide, MAL-PEG-MAL Cat. No. PG2-ML-10k 10000 Da 100 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Maleimide PEG Maleimide, MAL-PEG-MAL

Cat. No. PG2-ML-10k Maleimide PEG Maleimide, MAL-PEG-MAL           Cat. No. PG2-ML-10k     10000 Da    100 mg
Specification 10000 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Maleimide functionalized polyethylene glycol, Maleimide PEG is a sulfhydryl (thiol/SH) group reactive PEG derivative that can be used to selectively modify protein, peptide or any other surfaces with availablesulfhydryl groups. The reaction between maleimide and thiol proceeds readily at pH 6.5~7.5 to form stable thioether bonds.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated. Avoid frequent thaw and freeze.

Reaction Procedures:

Generally, a 10- to 20-fold molar excess of Maleimide PEG over the amount of thiol-containing material results in sufficient conjugation.

Materials Required:

  • Pegylation buffer, PBS buffer, pH 7 or other thiol-free buffer at pH 7.
  • Maleimide stock solution: 100 mg in 1 mL conjugation buffer.
  • Washing solution: Distilled water or any aqueous buffer.

Reaction Steps:

Dissolve targeted materials in conjugation buffer. Estimate the concentration thiol groups on the targeted materials. Add maleimide PEG stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. 10~50 molar excess of PEG maleimide needed for optimal conjugation; Allow mixture agitates at room temperature for 2~4 hours at room temperature or overnight at 4 0C.Conjugate can be purified either by size exclusion chromatography or dialysis.

Documents
  • SDS
  • DataSheet

Maleimide PEG Maleimide, MAL-PEG-MAL Cat. No. PG2-ML-1k 1000 Da 100 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Maleimide PEG Maleimide, MAL-PEG-MAL

Cat. No. PG2-ML-1k Maleimide PEG Maleimide, MAL-PEG-MAL           Cat. No. PG2-ML-1k     1000 Da    100 mg
Specification 1000 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Maleimide functionalized polyethylene glycol, Maleimide PEG is a sulfhydryl (thiol/SH) group reactive PEG derivative that can be used to selectively modify protein, peptide or any other surfaces with availablesulfhydryl groups. The reaction between maleimide and thiol proceeds readily at pH 6.5~7.5 to form stable thioether bonds.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated. Avoid frequent thaw and freeze.

Reaction Procedures:

Generally, a 10- to 20-fold molar excess of Maleimide PEG over the amount of thiol-containing material results in sufficient conjugation.

Materials Required:

  • Pegylation buffer, PBS buffer, pH 7 or other thiol-free buffer at pH 7.
  • Maleimide stock solution: 100 mg in 1 mL conjugation buffer.
  • Washing solution: Distilled water or any aqueous buffer.

Reaction Steps:

Dissolve targeted materials in conjugation buffer. Estimate the concentration thiol groups on the targeted materials. Add maleimide PEG stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. 10~50 molar excess of PEG maleimide needed for optimal conjugation; Allow mixture agitates at room temperature for 2~4 hours at room temperature or overnight at 4 0C.Conjugate can be purified either by size exclusion chromatography or dialysis.

Documents
  • SDS
  • DataSheet

Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA 

Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA 是一种抗体偶联药物,由抗肿瘤抗生素 Duocarmycin SA 和 Mal-PEG4-VC-PAB-DMEA-Seco 连接而成。

Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA

Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA Chemical Structure

CAS No. : 2259318-49-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA is a drug-linker conjugate for ADC by using the antitumor antibiotic, Duocarmycin SA, linked via Mal-PEG4-VC-PAB-DMEA-Seco.

IC50 & Target

Duocarmycins

 

分子量

1431.93

Formula

C67H87ClN12O21

CAS 号

2259318-49-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Maleimide PEG Maleimide, MAL-PEG-MAL Cat. No. PG2-ML-400 400 Da 100 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Maleimide PEG Maleimide, MAL-PEG-MAL

Cat. No. PG2-ML-400 Maleimide PEG Maleimide, MAL-PEG-MAL           Cat. No. PG2-ML-400     400 Da    100 mg
Specification 400 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Maleimide functionalized polyethylene glycol, Maleimide PEG is a sulfhydryl (thiol/SH) group reactive PEG derivative that can be used to selectively modify protein, peptide or any other surfaces with availablesulfhydryl groups. The reaction between maleimide and thiol proceeds readily at pH 6.5~7.5 to form stable thioether bonds.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated. Avoid frequent thaw and freeze.

Reaction Procedures:

Generally, a 10- to 20-fold molar excess of Maleimide PEG over the amount of thiol-containing material results in sufficient conjugation.

Materials Required:

  • Pegylation buffer, PBS buffer, pH 7 or other thiol-free buffer at pH 7.
  • Maleimide stock solution: 100 mg in 1 mL conjugation buffer.
  • Washing solution: Distilled water or any aqueous buffer.

Reaction Steps:

Dissolve targeted materials in conjugation buffer. Estimate the concentration thiol groups on the targeted materials. Add maleimide PEG stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. 10~50 molar excess of PEG maleimide needed for optimal conjugation; Allow mixture agitates at room temperature for 2~4 hours at room temperature or overnight at 4 0C.Conjugate can be purified either by size exclusion chromatography or dialysis.

Documents
  • SDS
  • DataSheet

Maleimide PEG Maleimide, MAL-PEG-MAL Cat. No. PG2-ML-600 600 Da 100 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Maleimide PEG Maleimide, MAL-PEG-MAL

Cat. No. PG2-ML-600 Maleimide PEG Maleimide, MAL-PEG-MAL           Cat. No. PG2-ML-600     600 Da    100 mg
Specification 600 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Maleimide functionalized polyethylene glycol, Maleimide PEG is a sulfhydryl (thiol/SH) group reactive PEG derivative that can be used to selectively modify protein, peptide or any other surfaces with availablesulfhydryl groups. The reaction between maleimide and thiol proceeds readily at pH 6.5~7.5 to form stable thioether bonds.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated. Avoid frequent thaw and freeze.

Reaction Procedures:

Generally, a 10- to 20-fold molar excess of Maleimide PEG over the amount of thiol-containing material results in sufficient conjugation.

Materials Required:

  • Pegylation buffer, PBS buffer, pH 7 or other thiol-free buffer at pH 7.
  • Maleimide stock solution: 100 mg in 1 mL conjugation buffer.
  • Washing solution: Distilled water or any aqueous buffer.

Reaction Steps:

Dissolve targeted materials in conjugation buffer. Estimate the concentration thiol groups on the targeted materials. Add maleimide PEG stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. 10~50 molar excess of PEG maleimide needed for optimal conjugation; Allow mixture agitates at room temperature for 2~4 hours at room temperature or overnight at 4 0C.Conjugate can be purified either by size exclusion chromatography or dialysis.

Documents
  • SDS
  • DataSheet

马来酰亚胺 PEG, mPEG-MAL, ,Maleimide PEG, mPEG-MAL,

马来酰亚胺 PEG, mPEG-MAL

MW 12000 Da

有货

马来酰亚胺 PEG, mPEG-MAL,  ,Maleimide PEG, mPEG-MAL,

品牌:Jinpan
Maleimide PEG, mPEG-MAL

MSDS

质检证书(CoA)

相似产品

货号 (SKU) 包装规格 是否现货 价格 数量
M163922-100mg 100mg 现货 马来酰亚胺 PEG, mPEG-MAL,  ,Maleimide PEG, mPEG-MAL,  
M163922-250mg 250mg 现货 马来酰亚胺 PEG, mPEG-MAL,  ,Maleimide PEG, mPEG-MAL,  
M163922-1g 1g 现货 马来酰亚胺 PEG, mPEG-MAL,  ,Maleimide PEG, mPEG-MAL,  

基本信息

产品名称 马来酰亚胺 PEG, mPEG-MAL
英文名称 Maleimide PEG, mPEG-MAL
规格或纯度 MW 12000 Da
运输条件 超低温冰袋运输

一般描述

Maleimide functionalized polyethylene glycol, Maleimide PEG is a sulfhydryl (thiol/SH) group reactive PEG derivative that can be used to selectively modify protein, peptide or any other surfaces with availablesulfhydryl groups. The reaction between maleimide and thiol proceeds readily at pH 6.5~7.5 to form stable thioether bonds.

Maleimide functionalized polyethylene glycol, Maleimide PEG is a sulfhydryl (thiol/SH) group reactive PEG derivative that can be used to selectively modify protein, peptide or any other surfaces with availablesulfhydryl groups. The reaction between maleimide and thiol proceeds readily at pH 6.5~7.5 to form stable thioether bonds.

相关属性

溶解性 Off-white/white solid or viscous liquid depends on molecule weight;Soluble in regular aqeous solution as well as most organic solvents;
储存温度 -20°C储存,充氩
品牌 Jinpan

Maleimide PEG Maleimide, MAL-PEG-MAL Cat. No. PG2-ML-20k 20000 Da 100 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Maleimide PEG Maleimide, MAL-PEG-MAL

Cat. No. PG2-ML-20k Maleimide PEG Maleimide, MAL-PEG-MAL           Cat. No. PG2-ML-20k     20000 Da    100 mg
Specification 20000 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Maleimide functionalized polyethylene glycol, Maleimide PEG is a sulfhydryl (thiol/SH) group reactive PEG derivative that can be used to selectively modify protein, peptide or any other surfaces with availablesulfhydryl groups. The reaction between maleimide and thiol proceeds readily at pH 6.5~7.5 to form stable thioether bonds.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated. Avoid frequent thaw and freeze.

Reaction Procedures:

Generally, a 10- to 20-fold molar excess of Maleimide PEG over the amount of thiol-containing material results in sufficient conjugation.

Materials Required:

  • Pegylation buffer, PBS buffer, pH 7 or other thiol-free buffer at pH 7.
  • Maleimide stock solution: 100 mg in 1 mL conjugation buffer.
  • Washing solution: Distilled water or any aqueous buffer.

Reaction Steps:

Dissolve targeted materials in conjugation buffer. Estimate the concentration thiol groups on the targeted materials. Add maleimide PEG stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. 10~50 molar excess of PEG maleimide needed for optimal conjugation; Allow mixture agitates at room temperature for 2~4 hours at room temperature or overnight at 4 0C.Conjugate can be purified either by size exclusion chromatography or dialysis.

Documents
  • SDS
  • DataSheet

Maleimide PEG Maleimide, MAL-PEG-MAL Cat. No. PG2-ML-35k 35000 Da 100 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Maleimide PEG Maleimide, MAL-PEG-MAL

Cat. No. PG2-ML-35k Maleimide PEG Maleimide, MAL-PEG-MAL           Cat. No. PG2-ML-35k     35000 Da    100 mg
Specification 35000 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Maleimide functionalized polyethylene glycol, Maleimide PEG is a sulfhydryl (thiol/SH) group reactive PEG derivative that can be used to selectively modify protein, peptide or any other surfaces with availablesulfhydryl groups. The reaction between maleimide and thiol proceeds readily at pH 6.5~7.5 to form stable thioether bonds.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated. Avoid frequent thaw and freeze.

Reaction Procedures:

Generally, a 10- to 20-fold molar excess of Maleimide PEG over the amount of thiol-containing material results in sufficient conjugation.

Materials Required:

  • Pegylation buffer, PBS buffer, pH 7 or other thiol-free buffer at pH 7.
  • Maleimide stock solution: 100 mg in 1 mL conjugation buffer.
  • Washing solution: Distilled water or any aqueous buffer.

Reaction Steps:

Dissolve targeted materials in conjugation buffer. Estimate the concentration thiol groups on the targeted materials. Add maleimide PEG stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. 10~50 molar excess of PEG maleimide needed for optimal conjugation; Allow mixture agitates at room temperature for 2~4 hours at room temperature or overnight at 4 0C.Conjugate can be purified either by size exclusion chromatography or dialysis.

Documents
  • SDS
  • DataSheet

Mal-PEG2-VCP-Eribulin

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Mal-PEG2-VCP-Eribulin 

Mal-PEG2-VCP-Eribulin 由 ADC linker (Mal-PEG2-VCP) 和 Eribulin 偶联而成。Eribulin 是一种独特的微管 (microtubule) 抑制剂,具有抗肿瘤活性。Mal-PEG2-VCP-Eribulin 可用于偶联抗体。

Mal-PEG2-VCP-Eribulin

Mal-PEG2-VCP-Eribulin Chemical Structure

CAS No. : 2130869-18-8

规格 价格 是否有货 数量
1 mg ¥25000 In-stock
5 mg ¥85000 In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

生物活性

Mal-PEG2-VCP-Eribulin consists the ADCs linker (Mal-PEG2-VCP) and Eribulin[1]. Eribulin is a mechanistically unique microtubule inhibitor for cancer[2]. Mal-PEG2-VCP-Eribulin is an Eribulin-based drug for antibody conjugates[1].

IC50 & Target

Traditional Cytotoxic Agents

 

分子量

1374.57

Formula

C70H99N7O21

CAS 号

2130869-18-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

参考文献
  • [1]. Earl F Albone, et al. Eribulin-based antibody-drug conjugates and methods of use. US20170252458A1.

    [2]. Towle MJ, et al. Eribulin induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions. Cancer Res. 2011 Jan 15;71(2):496-505.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

马来酰亚胺 PEG, mPEG-MAL, ,Maleimide PEG, mPEG-MAL,

马来酰亚胺 PEG, mPEG-MAL

MW 1000 Da

有货

马来酰亚胺 PEG, mPEG-MAL,  ,Maleimide PEG, mPEG-MAL,

品牌:Jinpan
Maleimide PEG, mPEG-MAL

MSDS

质检证书(CoA)

相似产品

货号 (SKU) 包装规格 是否现货 价格 数量
M163920-250mg 250mg 期货 马来酰亚胺 PEG, mPEG-MAL,  ,Maleimide PEG, mPEG-MAL,  
M163920-1g 1g 现货 马来酰亚胺 PEG, mPEG-MAL,  ,Maleimide PEG, mPEG-MAL,  

基本信息

产品名称 马来酰亚胺 PEG, mPEG-MAL
英文名称 Maleimide PEG, mPEG-MAL
规格或纯度 MW 1000 Da
运输条件 超低温冰袋运输

一般描述

Maleimide functionalized polyethylene glycol, Maleimide PEG is a sulfhydryl (thiol/SH) group reactive PEG derivative that can be used to selectively modify protein, peptide or any other surfaces with availablesulfhydryl groups. The reaction between maleimide and thiol proceeds readily at pH 6.5~7.5 to form stable thioether bonds.

Maleimide functionalized polyethylene glycol, Maleimide PEG is a sulfhydryl (thiol/SH) group reactive PEG derivative that can be used to selectively modify protein, peptide or any other surfaces with availablesulfhydryl groups. The reaction between maleimide and thiol proceeds readily at pH 6.5~7.5 to form stable thioether bonds.

相关属性

溶解性 Off-white/white solid or viscous liquid depends on molecule weight;Soluble in regular aqeous solution as well as most organic solvents;
储存温度 -20°C储存
品牌 Jinpan

马来酰亚胺 PEG, mPEG-MAL, ,Maleimide PEG, mPEG-MAL,

马来酰亚胺 PEG, mPEG-MAL

MW 40000 Da

有货

马来酰亚胺 PEG, mPEG-MAL,  ,Maleimide PEG, mPEG-MAL,

品牌:Jinpan
Maleimide PEG, mPEG-MAL

MSDS

质检证书(CoA)

相似产品

货号 (SKU) 包装规格 是否现货 价格 数量
M163927-250mg 250mg 现货 马来酰亚胺 PEG, mPEG-MAL,  ,Maleimide PEG, mPEG-MAL,  
M163927-1g 1g 现货 马来酰亚胺 PEG, mPEG-MAL,  ,Maleimide PEG, mPEG-MAL,  

基本信息

产品名称 马来酰亚胺 PEG, mPEG-MAL
英文名称 Maleimide PEG, mPEG-MAL
规格或纯度 MW 40000 Da
运输条件 超低温冰袋运输

一般描述

Maleimide functionalized polyethylene glycol, Maleimide PEG is a sulfhydryl (thiol/SH) group reactive PEG derivative that can be used to selectively modify protein, peptide or any other surfaces with availablesulfhydryl groups. The reaction between maleimide and thiol proceeds readily at pH 6.5~7.5 to form stable thioether bonds.

Maleimide functionalized polyethylene glycol, Maleimide PEG is a sulfhydryl (thiol/SH) group reactive PEG derivative that can be used to selectively modify protein, peptide or any other surfaces with availablesulfhydryl groups. The reaction between maleimide and thiol proceeds readily at pH 6.5~7.5 to form stable thioether bonds.

相关属性

敏感性 对光线敏感
溶解性 Off-white/white solid or viscous liquid depends on molecule weight;Soluble in regular aqeous solution as well as most organic solvents;
储存温度 避光,-20°C储存,充氩
品牌 Jinpan

马来酰亚胺 PEG, mPEG-MAL, ,Maleimide PEG, mPEG-MAL,

马来酰亚胺 PEG, mPEG-MAL

MW 5000 Da

有货

马来酰亚胺 PEG, mPEG-MAL,  ,Maleimide PEG, mPEG-MAL,

品牌:Jinpan
Maleimide PEG, mPEG-MAL

MSDS

质检证书(CoA)

相似产品

货号 (SKU) 包装规格 是否现货 价格 数量
M163928-1g 1g 现货 马来酰亚胺 PEG, mPEG-MAL,  ,Maleimide PEG, mPEG-MAL,  
M163928-5g 5g 现货 马来酰亚胺 PEG, mPEG-MAL,  ,Maleimide PEG, mPEG-MAL,  

基本信息

产品名称 马来酰亚胺 PEG, mPEG-MAL
英文名称 Maleimide PEG, mPEG-MAL
规格或纯度 MW 5000 Da
运输条件 超低温冰袋运输
生化机理

Generally, a 10- to 20-fold molar excess of Maleimide PEG over the amount of thiol-containing material results in sufficient conjμgation.

Materials Required:

  • Pegylation buffer, PBS buffer, pH 7 or other thiol-free buffer at pH 7.
  • Maleimide stock solution: 100 mg in 1 mL conjμgation buffer.
  • Washing solution: Distilled water or any aqueous buffer.

Reaction Steps:

Dissolve targeted materials in conjμgation buffer. Estimate the concentration thiol groups on the targeted materials. Add maleimide PEG stock solution to the targeted conjμgation materials with the final concentration keep at least 10 mg/mL. 10~50 molar excess of PEG maleimide needed for optimal conjμgation; Allow mixture agitates at room temperature for 2~4 hours at room temperature or overnight at 4 0C.Conjμgate can be purified either by size exclusion chromatography or dialysis.

一般描述

Maleimide functionalized polyethylene glycol, Maleimide PEG is a sulfhydryl (thiol/SH) group reactive PEG derivative that can be used to selectively modify protein, peptide or any other surfaces with availablesulfhydryl groups. The reaction between maleimide and thiol proceeds readily at pH 6.5~7.5 to form stable thioether bonds.

Maleimide functionalized polyethylene glycol, Maleimide PEG is a sulfhydryl (thiol/SH) group reactive PEG derivative that can be used to selectively modify protein, peptide or any other surfaces with availablesulfhydryl groups. The reaction between maleimide and thiol proceeds readily at pH 6.5~7.5 to form stable thioether bonds.

相关属性

敏感性 对空气敏感;对光敏感;对湿度敏感
溶解性 Off-white/white solid or viscous liquid depends on molecule weight;Soluble in regular aqeous solution as well as most organic solvents;
储存温度 避光,-20°C储存,充氩
品牌 Jinpan

马来酰亚胺 PEG, mPEG-MAL, ,Maleimide PEG, mPEG-MAL,

马来酰亚胺 PEG, mPEG-MAL

MW 550 Da

有货

马来酰亚胺 PEG, mPEG-MAL,  ,Maleimide PEG, mPEG-MAL,

品牌:Jinpan
Maleimide PEG, mPEG-MAL

MSDS

质检证书(CoA)

相似产品

货号 (SKU) 包装规格 是否现货 价格 数量
M163929-100mg 100mg 期货 马来酰亚胺 PEG, mPEG-MAL,  ,Maleimide PEG, mPEG-MAL,  
M163929-500mg 500mg 期货 马来酰亚胺 PEG, mPEG-MAL,  ,Maleimide PEG, mPEG-MAL,  

基本信息

产品名称 马来酰亚胺 PEG, mPEG-MAL
英文名称 Maleimide PEG, mPEG-MAL
规格或纯度 MW 550 Da
运输条件 超低温冰袋运输

一般描述

Maleimide functionalized polyethylene glycol, Maleimide PEG is a sulfhydryl (thiol/SH) group reactive PEG derivative that can be used to selectively modify protein, peptide or any other surfaces with availablesulfhydryl groups. The reaction between maleimide and thiol proceeds readily at pH 6.5~7.5 to form stable thioether bonds.

Maleimide functionalized polyethylene glycol, Maleimide PEG is a sulfhydryl (thiol/SH) group reactive PEG derivative that can be used to selectively modify protein, peptide or any other surfaces with availablesulfhydryl groups. The reaction between maleimide and thiol proceeds readily at pH 6.5~7.5 to form stable thioether bonds.

相关属性

溶解性 Off-white/white solid or viscous liquid depends on molecule weight;Soluble in regular aqeous solution as well as most organic solvents;
储存温度 -20°C储存,充氩
品牌 Jinpan

马来酰亚胺 PEG, mPEG-MAL, ,Maleimide PEG, mPEG-MAL,

马来酰亚胺 PEG, mPEG-MAL

MW 750 Da

有货

马来酰亚胺 PEG, mPEG-MAL,  ,Maleimide PEG, mPEG-MAL,

品牌:Jinpan
Maleimide PEG, mPEG-MAL

MSDS

质检证书(CoA)

相似产品

货号 (SKU) 包装规格 是否现货 价格 数量
M163930-100mg 100mg 期货 马来酰亚胺 PEG, mPEG-MAL,  ,Maleimide PEG, mPEG-MAL,  
M163930-1g 1g 期货 马来酰亚胺 PEG, mPEG-MAL,  ,Maleimide PEG, mPEG-MAL,  

基本信息

产品名称 马来酰亚胺 PEG, mPEG-MAL
英文名称 Maleimide PEG, mPEG-MAL
规格或纯度 MW 750 Da
运输条件 超低温冰袋运输

一般描述

Maleimide functionalized polyethylene glycol, Maleimide PEG is a sulfhydryl (thiol/SH) group reactive PEG derivative that can be used to selectively modify protein, peptide or any other surfaces with availablesulfhydryl groups. The reaction between maleimide and thiol proceeds readily at pH 6.5~7.5 to form stable thioether bonds.

Maleimide functionalized polyethylene glycol, Maleimide PEG is a sulfhydryl (thiol/SH) group reactive PEG derivative that can be used to selectively modify protein, peptide or any other surfaces with availablesulfhydryl groups. The reaction between maleimide and thiol proceeds readily at pH 6.5~7.5 to form stable thioether bonds.

相关属性

溶解性 Off-white/white solid or viscous liquid depends on molecule weight;Soluble in regular aqeous solution as well as most organic solvents;
储存温度 -20°C储存
品牌 Jinpan

Maleimide PEG Maleimide, MAL-PEG-MAL, ,Maleimide PEG Maleimide, MAL-PEG-MAL,

Maleimide PEG Maleimide, MAL-PEG-MAL

95%,MW 600 Da

有货

Maleimide PEG Maleimide, MAL-PEG-MAL,  ,Maleimide PEG Maleimide, MAL-PEG-MAL,

品牌:Jinpan
Maleimide PEG Maleimide, MAL-PEG-MAL

MSDS

质检证书(CoA)

相似产品

货号 (SKU) 包装规格 是否现货 价格 数量
M163907-100mg 100mg 现货 Maleimide PEG Maleimide, MAL-PEG-MAL,  ,Maleimide PEG Maleimide, MAL-PEG-MAL,  
M163907-500mg 500mg 现货 Maleimide PEG Maleimide, MAL-PEG-MAL,  ,Maleimide PEG Maleimide, MAL-PEG-MAL,  

基本信息

产品名称 Maleimide PEG Maleimide, MAL-PEG-MAL
英文名称 Maleimide PEG Maleimide, MAL-PEG-MAL
规格或纯度 95%,MW 600 Da
运输条件 超低温冰袋运输

一般描述

Maleimide functionalized polyethylene glycol, Maleimide PEG is a sulfhydryl (thiol/SH) group reactive PEG derivative that can be used to selectively modify protein, peptide or any other surfaces with availablesulfhydryl groups. The reaction between maleimide and thiol proceeds readily at pH 6.5~7.5 to form stable thioether bonds.

Maleimide functionalized polyethylene glycol, Maleimide PEG is a sulfhydryl (thiol/SH) group reactive PEG derivative that can be used to selectively modify protein, peptide or any other surfaces with availablesulfhydryl groups. The reaction between maleimide and thiol proceeds readily at pH 6.5~7.5 to form stable thioether bonds.

Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

相关属性

敏感性 对光敏感
溶解性 Off-white/white solid or viscous liquid depends on molecule weight;Soluble in regular aqeous solution as well as most organic solvents;
储存温度 避光,-20°C储存,充氩
品牌 Jinpan

马来酰亚胺 PEG N-羟基琥珀酰亚胺, MAL-PEG-NHS, ,Maleimide PEG NHS, MAL-PEG-NHS,

Maleimide PEG NHS, MAL-PEG-NHS

MW 1000 Da

有货

马来酰亚胺 PEG N-羟基琥珀酰亚胺, MAL-PEG-NHS,  ,Maleimide PEG NHS, MAL-PEG-NHS,

品牌:Jinpan
Maleimide PEG NHS, MAL-PEG-NHS

MSDS

质检证书(CoA)

相似产品

货号 (SKU) 包装规格 是否现货 价格 数量
M163908-100mg 100mg 现货 马来酰亚胺 PEG N-羟基琥珀酰亚胺, MAL-PEG-NHS,  ,Maleimide PEG NHS, MAL-PEG-NHS,  
M163908-500mg 500mg 期货 马来酰亚胺 PEG N-羟基琥珀酰亚胺, MAL-PEG-NHS,  ,Maleimide PEG NHS, MAL-PEG-NHS,  

基本信息

产品名称 Maleimide PEG NHS, MAL-PEG-NHS
英文名称 Maleimide PEG NHS, MAL-PEG-NHS
规格或纯度 MW 1000 Da
运输条件 超低温冰袋运输

一般描述

Maleimide PEG NHS is a heterobifunctional PEG derivative that can react with both thiol and amine groups. NHS esters react with deprotonated primary amines, therefore, the reaction requires neutral to basic pH values to proceed. The maleimide group reacts with available –SH groups from naturally occurring or mutagenically derived cysteine residues. Maleimide groups react with sulfhydryl groups at pH 6.5~7.5 at room temperature to form stable thioether bonds.

Maleimide PEG NHS is a heterobifunctional PEG derivative that can react with both thiol and amine groups. NHS esters react with deprotonated primary amines, therefore, the reaction requires neutral to basic pH values to proceed. The maleimide group reacts with available –SH groups from naturally occurring or mutagenically derived cysteine residues. Maleimide groups react with sulfhydryl groups at pH 6.5~7.5 at room temperature to form stable thioether bonds.

相关属性

敏感性 易吸潮
溶解性 Solubility: 10 mg/mL, clear in water,chloroform, DMSO.
储存温度 -20°C储存,充氩
品牌 Jinpan