I-191

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

I-191  纯度: 99.38%

I-191 是一种有效选择性的蛋白酶激活受体 2 (PAR2) 拮抗剂。

I-191

I-191 Chemical Structure

CAS No. : 1690172-25-8

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥3850 In-stock
5 mg ￥3500 In-stock
10 mg ￥5500 In-stock
25 mg ￥11000 In-stock
50 mg ￥16500 In-stock
100 mg ￥26500 In-stock
200 mg   询价  
500 mg   询价  

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I-191 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • GPCR/G Protein Compound Library
  • Immunology/Inflammation Compound Library
  • Anti-Cancer Compound Library
  • Targeted Diversity Library

生物活性

I-191 is a potent, selective protease-activated receptor 2 (PAR2) antagonist[1].

IC50 & Target

Protease-activated receptor 2[1]
体外研究
(In Vitro)

I-191 inhibits cytokine production as well as cytokine-related caspase cleavages via ERK1/2 signaling in HT29 colon cancer cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

423.48

Formula

C23H26FN5O2
CAS 号

1690172-25-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 8.33 mg/mL (19.67 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3614 mL 11.8069 mL 23.6139 mL
5 mM 0.4723 mL 2.3614 mL 4.7228 mL
10 mM 0.2361 mL 1.1807 mL 2.3614 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Jiang Y, et al. A Potent Antagonist of Protease-Activated Receptor 2 That Inhibits Multiple Signaling Functions in Human Cancer Cells. J Pharmacol Exp Ther. 2018 Feb;364(2):246-257.

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