STAT3-IN-3

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STAT3-IN-3  纯度: 98.08%

STAT3-IN-3 是一种有效和选择性的 STAT3 抑制剂，有抗增殖活性。STAT3-IN-3 可以引起乳腺癌细胞凋亡 (apoptosis)。STAT3-IN-3 是有前途的靶向线粒体的 STAT3 抑制剂，能用于癌症的研究。

STAT3-IN-3

STAT3-IN-3 Chemical Structure

CAS No. : 2361304-26-7

规格 价格 是否有货 数量
5 mg ￥3500 In-stock
10 mg ￥5500 In-stock
25 mg ￥11000 In-stock
50 mg ￥19500 In-stock
100 mg ￥35000 In-stock
200 mg   询价  
500 mg   询价  

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STAT3-IN-3 相关产品

•相关化合物库:

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生物活性

STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3), with anti-proliferative activity. STAT3-IN-3 induces apoptosis in breast cancer cells. STAT3-IN-3 acts as a promising mitochondria-targeting STAT3 inhibitor for cancer research[1].

IC50 & Target[1]

STAT3

 

体外研究
(In Vitro)

STAT3-IN-3 has no influence on the phosphorylation levels of STAT1, JAK2, Src and Erk1/2[1].
STAT3-IN-3 inhibits the growth of MDA-MB-231, HCT-116, HepG2, and MCF-7 cells with IC50s of 1.43 μM, 1.89 μM, 2.88 μM, and 3.33 μM, respectively[1].
STAT3-IN-3 down-regulates the expression of STAT3 target genes Bcl-2 and Cyclin D1[1].
STAT3-IN-3 inhibits STAT3 tyrosine phosphorylation and serine phosphorylation[1].
STAT3-IN-3 inhibits STAT3 DNA-binding activity[1].
STAT3-IN-3 (1-4 μM; 24 hours) increases ROS production and remarkably reduces the mitochondrial membrane potential to induce mitochondrial apoptotic pathway[1].
STAT3-IN-3 (1-4 μM; 24 hours) can induce the cleavage of caspase-9, caspase-3 and PARP[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MDA-MB-231 cells, HCT-116 cells, HepG2 cells, MCF-7cells
Concentration: MTT assay
Incubation Time: 48 hours
Result: Exhibited anti-proliferative activity.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 0 μM, 1 μM, 2 μM, 4 μM
Incubation Time: 24 hours
Result: Induced the apoptosis of MDA-MB-231 cells dose-dependently and the apoptosis rates.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 0 μM, 1 μM, 2 μM, 4 μM
Incubation Time: 24 hours
Result: Induced the cleavage of caspase-9, caspase-3 and PARP.

体内研究
(In Vivo)

STAT3-IN-3 (10mg/kg-20 mg/kg; i.p.; daily; for 14 days) possesses potent antitumor activity against implanted 4T1 breast tumors growth[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult female BALB/c mice (6 weeks of age)[1]
Dosage: 10 mg/kg, 20 mg/kg
Administration: Intraperitoneal injection, daily, for 14 days
Result: Significantly inhibited tumor volume.

分子量

600.48

Formula

C27H26BrN3O6S
CAS 号

2361304-26-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 5 mg/mL (8.33 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6653 mL 8.3267 mL 16.6533 mL
5 mM 0.3331 mL 1.6653 mL 3.3307 mL
10 mM — — —

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Cai G, et al. Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors. Eur J Med Chem. 2019 Jul 15;174:236-251.

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