Top1 inhibitor 1

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Top1 inhibitor 1 

Top1 inhibitor 1 (化合物 28) 是一种有效的人拓扑异构酶 1 (Top1) 抑制剂，IC50 值为 29 nM。

Top1 inhibitor 1

Top1 inhibitor 1 Chemical Structure

CAS No. : 2302772-05-8

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生物活性

Top1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC50 value of 29 nM[1].

IC50 & Target[1]

Camptothecins

 

体外研究
(In Vitro)

Top1 inhibitor 1 reveals cytotoxicity in cancerous cells including MCF7 (IC50: 2.74 µM), HeLa (IC50: 2.61 µM), HCT116 (IC50: 2.34 µM), NIH: OVCAR-3 (IC50: 2.35 µM) cells compared to the non-cancerous cells like HEK293 (IC50: 8.34 µM) [1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

426.47

Formula

C24H22N6O2
CAS 号

2302772-05-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kundu B, et al. Discovery and Mechanistic Study of Tailor-Made Quinoline Derivatives as Topoisomerase 1 Poison with Potent Anticancer Activity. J Med Chem. 2019 Apr 11; 62(7):3428-3446.

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