P-gp inhibitor 2

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P-gp inhibitor 2 

P-gp inhibitor 2 是一种有效的 P-gp 抑制剂。P-gp Inhibitor 2 在过表达 P-gp 的人结肠直肠癌细胞 (SW600 Ad300) 中显示出阿霉素耐药的逆转作用(IC50=0.22 µM)。

P-gp inhibitor 2

P-gp inhibitor 2 Chemical Structure

CAS No. : 2408406-89-1

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生物活性

P-gp inhibitor 2 is a potent P-gp inhibitor. P-gp inhibitor 2 shows reverse Doxorubicin resistance (IC50=0.22 µM) in P-gp overexpressing human colorectal carcinoma cells (SW600 Ad300)[1].

体外研究
(In Vitro)

P-gp inhibitor 2 (compound 2) exhibits no cytotoxicity (IC50>30 µM) toward human carcinoma (SW600) cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

498.53

Formula

C29H26N2O6

CAS 号

2408406-89-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Dewa AA, et al. Neochrysosporazines: Precursor-Directed Biosynthesis Defines a Marine-Derived Fungal Natural Product P-Glycoprotein Inhibitory Pharmacophore. J Med Chem. 2022, 65(3):2610-2622.

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