Becatecarin(Synonyms: NSC 655649; BMS 181176; BMY 27557)

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Becatecarin (Synonyms: NSC 655649; BMS 181176; BMY 27557)

Becatcarin是一种rebeccamycin类似物，具有抗肿瘤作用。Becatecarin插入DNA并抑制拓扑异构酶I/II的催化活性。

Becatecarin(Synonyms: NSC 655649; BMS 181176; BMY 27557)

Becatecarin Chemical Structure

CAS No. : 119673-08-4

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生物活性

Becatecarin is a rebeccamycin analog with antitumor effects. Becatecarin intercalates into DNA and inhibites the catalytic activity of topoisomerases I/II.

分子量

669.55

Formula

C33H34Cl2N4O7
CAS 号

119673-08-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Long BH, Rose WC, Vyas DM, Matson JA, Forenza S. Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles. Curr Med Chem Anticancer Agents. 2002;2(2):255-266.

    [2]. Robey RW, Obrzut T, Shukla S, et al. Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells. Cancer Chemother Pharmacol. 2009;64(3):575-583.

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