L-threo-PPMP

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L-threo-PPMP 

L-threo-PPMP 是一种 GlcT (UDP-Glc: Ceramide β1,1glucosyltransferase) 抑制剂。L-threo-PPMP 抑制鞘糖脂生物合成并诱导细胞凋亡。L-threo-PPMP 具有抗癌活性。

L-threo-PPMP

L-threo-PPMP Chemical Structure

CAS No. : 207278-87-3

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生物活性

L-threo-PPMP is a GlcT (UDP-Glc: Ceramide β1,1glucosyltransferase) inhibitor. L-threo-PPMP inhibits glycosphingolipid biosynthesis and induces apoptosis. L-threo-PPMP has anti-cancer activity[1].

体外研究
(In Vitro)

L-threo-PPMP (0.5-20 μM) induces apoptosis in carcinoma (Colo-205; SKBR3) cells after 6 h and damaging DNA between 24 and 48 h after treatment[1].
L-threo-PPMP (1-16 μM; 48 hours) includes Caspase-3 activation in breast cancer SKBR3 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

474.72

Formula

C29H50N2O3
CAS 号

207278-87-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Subhash Basu, et al. Apoptosis of human carcinoma cells in the presence of inhibitors of glycosphingolipid biosynthesis: I. Treatment of Colo-205 and SKBR3 cells with isomers of PDMP and PPMP. Glycoconj J. 2004;20(3):157-68.

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