Chlorambucil-d8-1(Synonyms: CB-1348-d8-1; WR-139013-d8-1)

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Chlorambucil-d8-1 (Synonyms: CB-1348-d8-1; WR-139013-d8-1)

Chlorambucil-d8-1 (CB-1348-d8-1) 是 Chlorambucil 的氘代物。Chlorambucil 是一种口服抗肿瘤活性剂和双功能烷基化剂 (alkylating agent),属于氮芥类。Chlorambucil 可用于研究淋巴细胞白血病、卵巢癌和乳腺癌以及霍奇金病。

Chlorambucil-d8-1(Synonyms: CB-1348-d8-1;  WR-139013-d8-1)

Chlorambucil-d8-1 Chemical Structure

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生物活性

Chlorambucil-d8-1 (CB-1348-d8-1) is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease[1][2][3][4].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

312.26

Formula

C14H11D8Cl2NO2

中文名称

苯丁酸氮芥 d8-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Guo JX, et al. Synergistic effects of chlorambucil and TRAIL on apoptosis and proliferation of Raji cells. Eur Rev Med Pharmacol Sci. 2017 Oct;21(20):4703-4710.

    [3]. Salem FS, et al. Biochemical and pathological studies on the effects of levamisole and chlorambucil on Ehrlich ascites carcinoma-bearing mice. Vet Ital. 2011 Jan-Mar;47(1):89-95.

    [4]. Mohamed D, et al. Chlorambucil-adducts in DNA analyzed at the oligonucleotide level using HPLC-ESI MS. Chem Res Toxicol. 2009;22(8):1435-1446.

    [5]. Birnbaum AD, et al. Chlorambucil and malignancy. Ophthalmology. 2010;117(7):1466-1466.e1.

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