LP-184

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

LP-184 

LP-184 (compound 6),一种酰基氟乙烯类似物,能够抑制肿瘤生长。LP-184 在卵巢、结肠、前列腺和胰腺细胞系中具有有效的抗癌活性,来自专利 WO2007019308A2。

LP-184

LP-184 Chemical Structure

CAS No. : 924835-67-6

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生物活性

LP-184 (compound 6), an acylfulvene analog, inhibits tumor growth. LP-184 has potent anti-cancer activity in the ovarian, colon, prostate and pancreatic cell lines. (patent WO2007019308A2).

IC50 & Target

IC50: 0.68 μM (HT29); 0.6 μM (OVCAR-3); 16 μM (AsPC-1); 0.14 μM (PC-3)

体外研究
(In Vitro)

LP-184 inhibits the growth of HT29, OVCAR-3, AsPC-1 and PC-3, with GI50s of 0.68, 0.6, 16 and 0.14 μM, respectively[1].
LP-184 displays IC50s of 800nM and 210 nM for anti-cancer activitie in the thymidine incorporation into cellular DNA (2 hour) and Trypan blue (48 hour) assay[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

LP-184 (7.5 and 10 mg/kg; i.p.; 21 day) has potent 15 anti-tumor activity against MV522 tumors, producing 4/6 and 5/5 partial responses, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (MV522 tumors) [1]
Dosage: 7.5 and 10 mg/kg
Administration: I.p; 21day
Result: Effective agent for human anti-tumor therapy.

分子量

304.34

Formula

C16H20N2O4

CAS 号

924835-67-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Trevor C. Mcmorris, et al. Illudin analogs useful as anticancer agents. WO2007019308A2.

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