Gyrophoric acid (Synonyms: 石耳酸)
Gyrophoric acid 是地衣种群中很好的紫外线滤光片。Gyrophoric acid 具有 DPPH 自由基清除活性，IC50值为 105.75 µg/ml。
Gyrophoric acid Chemical Structure
CAS No. : 548-89-0
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Gyrophoric acid is a good ultraviolet filter in lichen populations. Gyrophoric acid shows DPPH radical scavenging activity with an IC50 value of 105.75 µg/ml.
Gyrophoric acid (200 μM) leads to significant decrease of mitochondrial membrane potential in ovarian cancer cells A2780 after 24 h long exposure but not in HT-29 colon adenocarcinoma cells. Gyrophoric acid significantly inhibits cell growth and affects the expression of Bcl-2, Bax and Hsp70 proteins but only on higher concentration in A375 melanoma cancer cells. Gyrophoric acid treatment on HeLa cells clearly indicates ROS production and apoptosis as form of occurred cell death. Moreover, DNA damage and changing activity of stress/survival proteins as p38MAPK, Erk1/2 and Akt mediated by Gyrophoric acid treatment confirm pro-apoptotic potential.
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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