FGFR1 inhibitor-2

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FGFR1 inhibitor-2 

FGFR1 inhibitor-2 是一个 FGFR1 抑制剂(IC50 为 4.55 μM 在 MDA-MB-231细胞中)。FGFR1 inhibitor-2 可用于转移性三阴性乳腺癌的研究。

FGFR1 inhibitor-2

FGFR1 inhibitor-2 Chemical Structure

CAS No. : 2410612-08-5

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生物活性

FGFR1 inhibitor-2 is a FGFR1 inhibitor (IC50 is 4.55 μM in MDA-MB-231 cells). FGFR1 inhibitor-2 can be used for the research of metastatic triple-negative breast cancer[1].

IC50 & Target[1]

FGFR1

 

体外研究
(In Vitro)

FGFR1 inhibitor-2 (3 and 6 μM; 48 hours; MDA-MB-231) reduces the expression of FGFR1[1].
FGFR1 inhibitor-2 (0~5 μM; MDA-MB-231) increases the apoptotic index by 10.6-fold at 5 μM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MDA-MB-231
Concentration: 3 and 6 μM
Incubation Time: 48 hours
Result: Reduced the expression of FGFR1.

分子量

507.45

Formula

C25H22F5N3O3

CAS 号

2410612-08-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ashraf-Uz-Zaman M, et al. Design, synthesis and structure-activity relationship study of novel urea compounds as FGFR1 inhibitors to treat metastatic triple-negative breast cancer. Eur J Med Chem. 2021;209:112866.

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