Xylopine(Synonyms: 木番荔枝碱)

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Xylopine (Synonyms: 木番荔枝碱) 纯度: ≥98.0%

Xylopine 是一种阿朴啡生物碱,对癌细胞具有细胞毒活性。Xylopine 诱导氧化应激,导致癌细胞的 G2/M 细胞周期停滞和细胞凋亡 (apoptosis)。

Xylopine(Synonyms: 木番荔枝碱)

Xylopine Chemical Structure

CAS No. : 517-71-5

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生物活性

Xylopine is an aporphine alkaloid with cytotoxic activity on cancer cells. Xylopine induces oxidative stress, causes G2/M cell cycle arrest and apoptosis in cancer cells[1].

体外研究
(In Vitro)

Xylopine (3.5 μM-14 μM; 24-48 hours) displays potent cytotoxicity in a time- and does-depenpent manner[1].
Xylopine (72 h) has cytotoxic activity, with IC50 values ranging from 6.4 to 26.6 μM in eight different cancer cell lines (MCF7, HCT116, HepG2, SCC-9, HSC-3, HL-60, K-562, and B16-F10)[1].
Xylopine (3.5 μM-14 μM; 24-48 hours) causes cell cycle block at the phase G2/M, which is followed by internucleosomal DNA fragmentation[1].
Xylopine (3.5 μM-14 μM; 24-48 hours) significantly increases the early and late apoptosis, induces mitochondrial depolarization, and increases caspase-3 activation[1].
Xylopine also causes an increase in the production of reactive oxygen/nitrogen species (ROS/RNS), including hydrogen peroxide and nitric oxide, but not superoxide anion, and reduces glutathione levels are decreased in Xylopine-treated HCT116 cells[1]. HCT116 cells[1] 3.5 μM, 7 μM, and 14 μM 24 hours, 48 hours Induced G2/M phase arrest. HCT116 cells[1] 3.5 μM, 7 μM, and 14 μM 24 hours, 48 hours Significantly increased the early and late apoptosis.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HCT116 cells
Concentration: 3.5 μM, 7 μM, and 14 μM
Incubation Time: 24 hours, 48 hours
Result: Displayed potent cytotoxicity in HCT116 cells.

Cell Cycle Analysis[1]

Cell Line: HCT116 cells
Concentration: 3.5 μM, 7 μM, and 14 μM
Incubation Time: 24 hours, 48 hours
Result: Induced G2/M phase arrest.

Apoptosis Analysis[1]

Cell Line: HCT116 cells
Concentration: 3.5 μM, 7 μM, and 14 μM
Incubation Time: 24 hours, 48 hours
Result: Significantly increased the early and late apoptosis.

分子量

295.33

Formula

C18H17NO3

CAS 号

517-71-5

中文名称

木番荔枝碱

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献
  • [1]. Luciano de Souza Santos, et al. Xylopine Induces Oxidative Stress and Causes G 2/M Phase Arrest, Triggering Caspase-Mediated Apoptosis by p53-Independent Pathway in HCT116 Cells. Oxid Med Cell Longev. 2017;2017:7126872.

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