Pendulone(Synonyms: 垂崖豆藤异黄烷醌)

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Pendulone (Synonyms: 垂崖豆藤异黄烷醌)

Pendulone 是一种异黄烷醌,具有良好的抗疟原虫活性,IC50 为 7.0 µM。Pendulone 还具有抗利什曼原虫、抗菌和抗癌活性。

Pendulone(Synonyms: 垂崖豆藤异黄烷醌)

Pendulone Chemical Structure

CAS No. : 69359-09-7

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生物活性

Pendulone is a isoflavanquinone with good antiplasmodial activity with an IC50 of 7.0 µM. Pendulone also has antileishmanial, antibacterial and anticancer activity[1][2].

体外研究
(In Vitro)

Pendulone displays moderate antiproliferative activity against the A2780 human ovarian cancer cell line, with an IC50 value 19.6 µM[1].
Pendulone displays an IC50 value of 0.43 µg/mL, against L. donovani promastigotes. Pendulone also displays antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus (each IC50 of 1.44 µg/mL)[2].
Pendulone exhibits moderate anticancer activity against human cancer cell lines (SK-MEL, KB, BT-549 and SK-OV-3) with IC50 values of 5.5 and 10.5 μg/mL. Pendulone also shows moderate cytotoxicities against monkey kidney fibroblasts (VERO) and pig kidney epithelial cells (LLC-PK11)[2].
Pendulone shows strong inhibition on the effect of the cell cycle induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in Raji cells[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Pendulone shows potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test of mouse skin using 7,12-dimethylbenz[a]-anthracene and TPA[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

316.31

Formula

C17H16O6

CAS 号

69359-09-7

中文名称

垂崖豆藤异黄烷醌

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Qingxi Su, et al. Antiplasmodial Isoflavanes and Pterocarpans from Apoplanesia paniculata. Planta Med. 2015 Aug;81(12-13):1128-32.

    [2]. Aziz A Rahman, et al. Antiparasitic and antimicrobial isoflavanquinones from Abrus schimperi. Nat Prod Commun. 2011 Nov;6(11):1645-50.

    [3]. T Konoshima, et al. Anti-tumor promoting activities of isoflavonoids from Wistaria brachybotrys. Biol Pharm Bull. 1997 Aug;20(8):865-8.

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