Antitumor agent-28

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Antitumor agent-28 

Antitumor agent-28 选择性调节共济失调毛细血管扩张突变 (ATM) 激酶。Antitumor agent-28 可预防 ATM 介导的疾病并具有有效的抗癌活性。

Antitumor agent-28

Antitumor agent-28 Chemical Structure

CAS No. : 2097499-67-5

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生物活性

Antitumor agent-28 selectively inhibits ataxia telangiectasia mutated (ATM) kinase. Antitumor agent-28 prevents ATM mediated disease and has potent anti-cancer activity[1].

IC50 & Target[1]

ATM

 

ATR

 

体外研究
(In Vitro)

Antitumor agent-28 inhibits ataxia telangiectasia mutated (ATM; IC50=7.6 nM; HT29 cells), ataxia telangiectasia and Rad3-related protein (ATR; IC50=18 μM; HT29 cells), PI3Ka (IC50=0.24 μM; BT474 cells). Antitumor agent-28 does not inhibit mTOR in MDA-MB-468 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

512.62

Formula

C25H32N6O4S
CAS 号

2097499-67-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kurt Gordon Pike, et al. Composés imidazo[4,5c]quinoline-2-one et leur utilisation dans le traitement du cancer. WO2017076898A1.

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