SCD1 inhibitor-3

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

SCD1 inhibitor-3 

SCD1 inhibitor-3 是一种安全、有效的具有口服活性的 SCD1 抑制剂。SCD1 inhibitor-3 可用于肥胖症、二型糖尿病、血脂异常等代谢性疾病，以及皮肤病、痤疮、癌症等的研究。

SCD1 inhibitor-3

SCD1 inhibitor-3 Chemical Structure

CAS No. : 1282606-48-7

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生物活性

SCD1 inhibitor-3 is a safe, potent and orally active SCD1 inhibitor. SCD1 inhibitor-3 can be used for the research of metabolic diseases such as obesity, type II diabetes and dyslipidemia, as well as skin diseases, acne and cancer[1].

IC50 & Target

SCD1[1]
体内研究
(In Vivo)

SCD1 inhibitor-3 (compound 17a) (5 mg/kg; p.o.; 4 hours) reduces the plasma C16:1/C16:0 triglycerides desaturation index by 54 %[1].
SCD1 inhibitor-3 (2~10 mg/kg; p.o.; 4 hours) makes a dose-responsive reduction of plasma triglycerides desaturation index[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lewis rats[1]
Dosage: 5 mg/kg
Administration: P.o.; 4 hours
Result: Reduced the plasma C16:1/C16:0 triglycerides desaturation index by 54 %.
Animal Model: Lewis rats[1]
Dosage: 2~10 mg/kg
Administration: P.o.; 4 hours
Result: A dose-responsive reduction of plasma triglycerides desaturation index.

分子量

393.37

Formula

C19H16FN7O2
CAS 号

1282606-48-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sun S, et al. Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors. Bioorg Med Chem. 2015;23(3):455-465.

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