Methyl pyropheophorbide-a(Synonyms: Pyropheophorbide-a methyl ester)

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Methyl pyropheophorbide-a (Synonyms: Pyropheophorbide-a methyl ester)

Methyl pyropheophorbide-a (Pyropheophorbide-a methyl ester)，叶绿素 a 的衍生物，是一种有效的光敏剂，可用于癌症的光动力疗法 (PDT)。Methyl pyropheophorbide-a 具有光动力学活性，可以诱导细胞凋亡并抑制肿瘤的生长。

Methyl pyropheophorbide-a(Synonyms: Pyropheophorbide-a methyl ester)

Methyl pyropheophorbide-a Chemical Structure

CAS No. : 6453-67-4

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生物活性

Methyl pyropheophorbide-a (Pyropheophorbide-a methyl ester), a chlorophyll-a derivative, is a potent photosensitizer that can be used in photodynamic therapy (PDT) of cancer. Methyl pyropheophorbide-a has photodynamic activity and can induce apoptosis and inhibit tumor growth[1][2].

体外研究
(In Vitro)

Pyropheophorbide-a methyl ester (2 μM; 12 h) inhibits the cell cycle progression from the G0/G1-phases and induces apoptosis at the light dosage of 55.6 kJ/m2 in PC-3M cells[2].
Pyropheophorbide-a methyl ester (0.2-15 μM; 20 h) has no significant dark cytotoxicity in NCI-h446 cells[1].
Pyropheophorbide-a methyl ester (0.1-15 μM; 20 h) mediates a dose-dependent photocytotoxicity in the NCI-h446 cells[1].
Pyropheophorbide-a methyl ester (2-4 μM; 0-24 h) induces apoptosis of NCI-h446 cells in a time-dependent manner[1].
Pyropheophorbide-a methyl ester (0.5-4 μM; 0-20 h) shows a photocytotoxicity in PC-3M cells[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: PC-3M cells
Concentration: 2 μM
Incubation Time: 12 h
Result: Apoptosis rate was about 0.27%, 6.15%, 20.49%, 50.76%, 65.39%, 64.92%, and 64.37% at 1, 3, 6, 12, 18, and 24 h posttreatment, respectively under the conditions of LC75 (2 μM+55.6 kJ/m2).

体内研究
(In Vivo)

Pyropheophorbide-a methyl ester (15 mg/kg; tail vein and topical injection) inhibits the growth of PC-3M tumors in mice[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c nude mice (6-8 weeks, 16-20 g) bearing PC-3M tumor[2]
Dosage: 15 mg/kg
Administration: Tail vein injection and topical injection
Result: The tumor volume and the weight inhibition rate were 46.78%, 41.84% in tail vein injection group and 78.66%, 72.07% in topical injection group, respectively.

分子量

548.67

Formula

C34H36N4O3
CAS 号

6453-67-4
中文名称

焦脱镁叶绿酸 a 甲酯
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sun X, et, al. Photodynamic therapy with pyropheophorbide-a methyl ester in human lung carcinoma cancer cell: efficacy, localization and apoptosis. Photochem Photobiol. 2002 Jun;75(6):644-51.

    [2]. Tian Y, et, al. Cell death induced by MPPa-PDT in prostate carcinoma in vitro and in vivo. Biochem Biophys Res Commun. 2006 Sep 22;348(2):413-20.

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