标签归档：pyropheophorbide

Methyl pyropheophorbide-a(Synonyms: Pyropheophorbide-a methyl ester)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Methyl pyropheophorbide-a (Synonyms: Pyropheophorbide-a methyl ester)

Methyl pyropheophorbide-a (Pyropheophorbide-a methyl ester)，叶绿素 a 的衍生物，是一种有效的光敏剂，可用于癌症的光动力疗法 (PDT)。Methyl pyropheophorbide-a 具有光动力学活性，可以诱导细胞凋亡并抑制肿瘤的生长。

Methyl pyropheophorbide-a(Synonyms: Pyropheophorbide-a methyl ester)

Methyl pyropheophorbide-a Chemical Structure

CAS No. : 6453-67-4

规格 是否有货
1 mg 询价
5 mg 询价

* Please select Quantity before adding items.

生物活性

Methyl pyropheophorbide-a (Pyropheophorbide-a methyl ester), a chlorophyll-a derivative, is a potent photosensitizer that can be used in photodynamic therapy (PDT) of cancer. Methyl pyropheophorbide-a has photodynamic activity and can induce apoptosis and inhibit tumor growth[1][2].

体外研究
(In Vitro)

Pyropheophorbide-a methyl ester (2 μM; 12 h) inhibits the cell cycle progression from the G0/G1-phases and induces apoptosis at the light dosage of 55.6 kJ/m2 in PC-3M cells[2].
Pyropheophorbide-a methyl ester (0.2-15 μM; 20 h) has no significant dark cytotoxicity in NCI-h446 cells[1].
Pyropheophorbide-a methyl ester (0.1-15 μM; 20 h) mediates a dose-dependent photocytotoxicity in the NCI-h446 cells[1].
Pyropheophorbide-a methyl ester (2-4 μM; 0-24 h) induces apoptosis of NCI-h446 cells in a time-dependent manner[1].
Pyropheophorbide-a methyl ester (0.5-4 μM; 0-20 h) shows a photocytotoxicity in PC-3M cells[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: PC-3M cells
Concentration: 2 μM
Incubation Time: 12 h
Result: Apoptosis rate was about 0.27%, 6.15%, 20.49%, 50.76%, 65.39%, 64.92%, and 64.37% at 1, 3, 6, 12, 18, and 24 h posttreatment, respectively under the conditions of LC75 (2 μM+55.6 kJ/m2).

体内研究
(In Vivo)

Pyropheophorbide-a methyl ester (15 mg/kg; tail vein and topical injection) inhibits the growth of PC-3M tumors in mice[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c nude mice (6-8 weeks, 16-20 g) bearing PC-3M tumor[2]
Dosage: 15 mg/kg
Administration: Tail vein injection and topical injection
Result: The tumor volume and the weight inhibition rate were 46.78%, 41.84% in tail vein injection group and 78.66%, 72.07% in topical injection group, respectively.

分子量

548.67

Formula

C34H36N4O3
CAS 号

6453-67-4
中文名称

焦脱镁叶绿酸 a 甲酯
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sun X, et, al. Photodynamic therapy with pyropheophorbide-a methyl ester in human lung carcinoma cancer cell: efficacy, localization and apoptosis. Photochem Photobiol. 2002 Jun;75(6):644-51.

    [2]. Tian Y, et, al. Cell death induced by MPPa-PDT in prostate carcinoma in vitro and in vivo. Biochem Biophys Res Commun. 2006 Sep 22;348(2):413-20.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Methyl pyropheophorbide-a(Synonyms: Pyropheophorbide-a methyl ester)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Methyl pyropheophorbide-a (Synonyms: Pyropheophorbide-a methyl ester)

Methyl pyropheophorbide-a (Pyropheophorbide-a methyl ester)，叶绿素 a 的衍生物，是一种有效的光敏剂，可用于癌症的光动力疗法 (PDT)。Methyl pyropheophorbide-a 具有光动力学活性，可以诱导细胞凋亡并抑制肿瘤的生长。

Methyl pyropheophorbide-a(Synonyms: Pyropheophorbide-a methyl ester)

Methyl pyropheophorbide-a Chemical Structure

CAS No. : 6453-67-4

规格 是否有货
1 mg 询价
5 mg 询价

* Please select Quantity before adding items.

生物活性

Methyl pyropheophorbide-a (Pyropheophorbide-a methyl ester), a chlorophyll-a derivative, is a potent photosensitizer that can be used in photodynamic therapy (PDT) of cancer. Methyl pyropheophorbide-a has photodynamic activity and can induce apoptosis and inhibit tumor growth[1][2].

体外研究
(In Vitro)

Pyropheophorbide-a methyl ester (2 μM; 12 h) inhibits the cell cycle progression from the G0/G1-phases and induces apoptosis at the light dosage of 55.6 kJ/m2 in PC-3M cells[2].
Pyropheophorbide-a methyl ester (0.2-15 μM; 20 h) has no significant dark cytotoxicity in NCI-h446 cells[1].
Pyropheophorbide-a methyl ester (0.1-15 μM; 20 h) mediates a dose-dependent photocytotoxicity in the NCI-h446 cells[1].
Pyropheophorbide-a methyl ester (2-4 μM; 0-24 h) induces apoptosis of NCI-h446 cells in a time-dependent manner[1].
Pyropheophorbide-a methyl ester (0.5-4 μM; 0-20 h) shows a photocytotoxicity in PC-3M cells[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: PC-3M cells
Concentration: 2 μM
Incubation Time: 12 h
Result: Apoptosis rate was about 0.27%, 6.15%, 20.49%, 50.76%, 65.39%, 64.92%, and 64.37% at 1, 3, 6, 12, 18, and 24 h posttreatment, respectively under the conditions of LC75 (2 μM+55.6 kJ/m2).

体内研究
(In Vivo)

Pyropheophorbide-a methyl ester (15 mg/kg; tail vein and topical injection) inhibits the growth of PC-3M tumors in mice[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c nude mice (6-8 weeks, 16-20 g) bearing PC-3M tumor[2]
Dosage: 15 mg/kg
Administration: Tail vein injection and topical injection
Result: The tumor volume and the weight inhibition rate were 46.78%, 41.84% in tail vein injection group and 78.66%, 72.07% in topical injection group, respectively.

分子量

548.67

Formula

C34H36N4O3
CAS 号

6453-67-4
中文名称

焦脱镁叶绿酸 a 甲酯
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sun X, et, al. Photodynamic therapy with pyropheophorbide-a methyl ester in human lung carcinoma cancer cell: efficacy, localization and apoptosis. Photochem Photobiol. 2002 Jun;75(6):644-51.

    [2]. Tian Y, et, al. Cell death induced by MPPa-PDT in prostate carcinoma in vitro and in vivo. Biochem Biophys Res Commun. 2006 Sep 22;348(2):413-20.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Methyl pyropheophorbide-a(Synonyms: Pyropheophorbide-a methyl ester)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Methyl pyropheophorbide-a (Synonyms: Pyropheophorbide-a methyl ester)

Methyl pyropheophorbide-a (Pyropheophorbide-a methyl ester)，叶绿素 a 的衍生物，是一种有效的光敏剂，可用于癌症的光动力疗法 (PDT)。Methyl pyropheophorbide-a 具有光动力学活性，可以诱导细胞凋亡并抑制肿瘤的生长。

Methyl pyropheophorbide-a(Synonyms: Pyropheophorbide-a methyl ester)

Methyl pyropheophorbide-a Chemical Structure

CAS No. : 6453-67-4

规格 是否有货
1 mg 询价
5 mg 询价

* Please select Quantity before adding items.

生物活性

Methyl pyropheophorbide-a (Pyropheophorbide-a methyl ester), a chlorophyll-a derivative, is a potent photosensitizer that can be used in photodynamic therapy (PDT) of cancer. Methyl pyropheophorbide-a has photodynamic activity and can induce apoptosis and inhibit tumor growth[1][2].

体外研究
(In Vitro)

Pyropheophorbide-a methyl ester (2 μM; 12 h) inhibits the cell cycle progression from the G0/G1-phases and induces apoptosis at the light dosage of 55.6 kJ/m2 in PC-3M cells[2].
Pyropheophorbide-a methyl ester (0.2-15 μM; 20 h) has no significant dark cytotoxicity in NCI-h446 cells[1].
Pyropheophorbide-a methyl ester (0.1-15 μM; 20 h) mediates a dose-dependent photocytotoxicity in the NCI-h446 cells[1].
Pyropheophorbide-a methyl ester (2-4 μM; 0-24 h) induces apoptosis of NCI-h446 cells in a time-dependent manner[1].
Pyropheophorbide-a methyl ester (0.5-4 μM; 0-20 h) shows a photocytotoxicity in PC-3M cells[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: PC-3M cells
Concentration: 2 μM
Incubation Time: 12 h
Result: Apoptosis rate was about 0.27%, 6.15%, 20.49%, 50.76%, 65.39%, 64.92%, and 64.37% at 1, 3, 6, 12, 18, and 24 h posttreatment, respectively under the conditions of LC75 (2 μM+55.6 kJ/m2).

体内研究
(In Vivo)

Pyropheophorbide-a methyl ester (15 mg/kg; tail vein and topical injection) inhibits the growth of PC-3M tumors in mice[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c nude mice (6-8 weeks, 16-20 g) bearing PC-3M tumor[2]
Dosage: 15 mg/kg
Administration: Tail vein injection and topical injection
Result: The tumor volume and the weight inhibition rate were 46.78%, 41.84% in tail vein injection group and 78.66%, 72.07% in topical injection group, respectively.

分子量

548.67

Formula

C34H36N4O3
CAS 号

6453-67-4
中文名称

焦脱镁叶绿酸 a 甲酯
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sun X, et, al. Photodynamic therapy with pyropheophorbide-a methyl ester in human lung carcinoma cancer cell: efficacy, localization and apoptosis. Photochem Photobiol. 2002 Jun;75(6):644-51.

    [2]. Tian Y, et, al. Cell death induced by MPPa-PDT in prostate carcinoma in vitro and in vivo. Biochem Biophys Res Commun. 2006 Sep 22;348(2):413-20.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Pyropheophorbide-a

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Pyropheophorbide-a  纯度: 92.77%

Pyropheophorbide-a (Ppa) 是用于肿瘤光动力疗法 (PDT) 的光敏剂。

Pyropheophorbide-a

Pyropheophorbide-a Chemical Structure

CAS No. : 24533-72-0

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥650 In-stock
5 mg ￥550 In-stock
10 mg ￥1000 In-stock
25 mg ￥2200 In-stock
50 mg ￥3600 In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Pyropheophorbide-a 相关产品

•相关化合物库:

  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Anti-Cancer Compound Library
  • Clinical Compound Library
  • Drug Repurposing Compound Library
  • Food-Sourced Compound Library

生物活性

Pyropheophorbide-a (Ppa) is a promising photosensitizer for tumor photodynamic therapy (PDT)[1].

Clinical Trial

分子量

534.65

Formula

C33H34N4O3
CAS 号

24533-72-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 12.5 mg/mL (23.38 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8704 mL 9.3519 mL 18.7038 mL
5 mM 0.3741 mL 1.8704 mL 3.7408 mL
10 mM 0.1870 mL 0.9352 mL 1.8704 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.25 mg/mL (2.34 mM); Clear solution

    此方案可获得 ≥ 1.25 mg/mL (2.34 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 12.5 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 1.25 mg/mL (2.34 mM); Clear solution

    此方案可获得 ≥ 1.25 mg/mL (2.34 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 12.5 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Li W, et al. cRGD Peptide-Conjugated Pyropheophorbide-a Photosensitizers for Tumor Targeting in Photodynamic Therapy. Mol Pharm. 2018 Apr 2;15(4):1505-1514.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务