m-PEG12-OH

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

m-PEG12-OH 

m-PEG12-OH 是一种 PROTAC linker,属于 PEG 类,可用于合成 PROTAC 分子。m-PEG12-OH 也是一种不可降解 (non-cleavable) 的含 12 个单元 PEG 的 ADC linker,可用于合成抗体偶联药物 (ADC)。

m-PEG12-OH

m-PEG12-OH Chemical Structure

CAS No. : 2050595-03-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

m-PEG12-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG12-OH is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

IC50 & Target[1][2]

PEGs

 

Non-cleavable

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

560.67

Formula

C25H52O13

CAS 号

2050595-03-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Kachbi-Khelfallah S, et al. Towards potential nanoparticle contrast agents: Synthesis of new functionalized PEG bisphosphonates. Beilstein J Org Chem. 2016 Jul 4;12:1366-71.

    [2]. Hamura, Mika, et al. Branched monodispersed polyethylene glycol, intermediate, and method for producing same. WO 2019181984 A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务