m-PEG10-alcohol(Synonyms: Decaethylene glycol monomethyl ether)

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m-PEG10-alcohol (Synonyms: Decaethylene glycol monomethyl ether)

m-PEG10-alcohol (Decaethylene glycol monomethyl ether) 是一种不可降解 (non-cleavable) 的含 10 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。m-PEG10-alcohol 还是一种 PROTAC linker，属于 PEG 类，可用于合成 PROTAC 分子。

m-PEG10-alcohol(Synonyms: Decaethylene glycol monomethyl ether)

m-PEG10-alcohol Chemical Structure

CAS No. : 27425-92-9

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生物活性

m-PEG10-alcohol (Decaethylene glycol monomethyl ether) is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG10-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

PEGs

 

Non-cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

472.57

Formula

C21H44O11
CAS 号

27425-92-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Nnochiri Ekwuribe, et al. Calcitonin drug-oligomer conjugates, and uses thereof. US20040091452A1.

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