Acid-PEG3-C2-Boc

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Acid-PEG3-C2-Boc 

Acid-PEG3-C2-Boc是一种 PROTAC linker，属于 PEG 和 Alkyl/ether 类，可以用于合成降解 EGFR 和抑制 mTOR 的 PROTAC。

Acid-PEG3-C2-Boc

Acid-PEG3-C2-Boc Chemical Structure

CAS No. : 1807539-06-5

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生物活性

Acid-PEG3-C2-Boc is a PEG– and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs for the degradation of EGFR and inhibition of mTOR[1][2].

IC50 & Target

PEGs

 

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

306.35

Formula

C14H26O7
CAS 号

1807539-06-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Nathanael Gray, et al. Bifunctional molecules for degradation of egfr and methods of use. WO2017185036A1.

    [2]. Christopher Semko, et al. Rapamycin analogs as mtor inhibitors. WO 2018204416 A1.

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