N-(Amino-PEG5)-N-bis(PEG4-acid) | 赛默飞Alfa aesar官网

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N-(Amino-PEG5)-N-bis(PEG4-acid)

N-(Amino-PEG5)-N-bis(PEG4-acid) 是一种 PEG 类 PROTAC linker，可用于合成 PROTAC。N-(Amino-PEG5)-N-bis(PEG4-acid) 含有一个带有两个末端羧酸的氨基。

N-(Amino-PEG5)-N-bis(PEG4-acid) Chemical Structure

CAS No. : 2093152-86-2

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性

N-(Amino-PEG5)-N-bis(PEG4-acid) is a PEG-based PROTAC linker used in the synthesis of PROTACs. N-(Amino-PEG5)-N-bis(PEG4-acid) contains an amino group with two terminal carboxylic acids^[1].

IC₅₀ & Target

PEGs

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

776.91

Formula

C₃₄H₆₈N₂O₁₇

CAS 号

2093152-86-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Pignatello, R., et al. New amphiphilic derivatives of poly(ethylene glycol) (PEG) as surface modifiers of colloidal drug carriers. III. Lipoamino acid conjugates with carboxy- and amino-PEG5000 polymers. Materials Science and Engineering: C, 2015.46, 470–481.

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