Bis-PEG2-PFP ester

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Bis-PEG2-PFP ester 

NH2-PEG3-BOC 是一种不可降解 (non-cleavable) 的含 2 个单元 PEG 的 ADC linker,可用于合成抗体偶联药物 (ADC)。Bis-PEG2-PFP ester 也是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

Bis-PEG2-PFP ester

Bis-PEG2-PFP ester Chemical Structure

CAS No. : 1314378-18-1

规格 是否有货
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生物活性

Bis-PEG2-PFP ester is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Bis-PEG2-PFP ester is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

IC50 & Target

PEGs

 

Alkyl/ether

 

Non-cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

538.29

Formula

C20H12F10O6

CAS 号

1314378-18-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Matthew David DOROSKI, et al. Cytotoxic peptides and antibody drug conjugates thereof. WO2013072813A2.

    [2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

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