Bis-propargyl-PEG2

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Bis-propargyl-PEG2 

Bis-propargyl-PEG2 是一种 PROTAC linker，属于 PEG类，可以用于合成 PROTAC。Bis-propargyl-PEG2 被用于合成去甲万古霉素。

Bis-propargyl-PEG2

Bis-propargyl-PEG2 Chemical Structure

CAS No. : 126422-57-9

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生物活性

Bis-propargyl-PEG2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-propargyl-PEG2 is used for the synthesis of demethylvancomycin dimers[1][2].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

Bis-propargyl-PEG2 can be used in the synthesis of demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

182.22

Formula

C10H14O3
CAS 号

126422-57-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Shenoi RA, et al. Synthesis, characterization, and biocompatibility of biodegradable hyperbranched polyglycerols from acid-cleavable ketal group functionalized initiators. Biomacromolecules. 2012 Oct 8;13(10):3018-30.

    [2]. Jiang, et al. Design, synthesis and biological activity of novel demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis. Tetrahedron, 2018: 74(27), 3527–3533.

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