Capecitabine-d11(Synonyms: 卡培他滨 d11)

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Capecitabine-d11 (Synonyms: 卡培他滨 d11)

Capecitabine-d11 是 Capecitabine 的氘代物。Capecitabine 是一种可用于口服的前药，可由胸苷磷酸化酶催化转变为其活性代谢物 Fluorouracil (FU)。

Capecitabine-d11(Synonyms: 卡培他滨 d11)

Capecitabine-d11 Chemical Structure

CAS No. : 1132662-08-8

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生物活性

Capecitabine-d11 is the deuterium labeled Capecitabine. Capecitabine is an oral prodrug that is converted to its active metabolite, 5-FU, by thymidine phosphorylase[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

370.42

Formula

C15H11D11FN3O6
CAS 号

1132662-08-8
中文名称

卡培他滨 d11
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. PharmD CM, et al. Capecitabine: A review. Clinical Therapeutics. 2005 Jan; 27(1): 23-44.

    [3]. Guichard SM, et al. Gene expression predicts differential capecitabine metabolism, impacting on both pharmacokinetics and antitumour activity. Eur J Cancer. 2008 Jan;44(2):310-7.

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